The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling

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dc.contributor.authorShabalala, Samukelisiwe C.en_ZA
dc.contributor.authorDludla, Phiwayinkosi V.en_ZA
dc.contributor.authorMabasa, Lawrenceen_ZA
dc.contributor.authorKappo, Abidemi P.en_ZA
dc.contributor.authorBasson, Albertus K.en_ZA
dc.contributor.authorPheiffer, Carmenen_ZA
dc.contributor.authorJohnson, Rabiaen_ZA
dc.date.accessioned2022-05-03T07:27:16Zen_ZA
dc.date.available2022-05-03T07:27:16Zen_ZA
dc.date.issued2020-09en_ZA
dc.descriptionCITATION: Shabalala, Samukelisiwe C. et al. 2020. The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling. Biomed Pharmacotherapy, 131:110785, doi:10.1016/j.biopha.2020.110785.en_ZA
dc.descriptionThe original publication is available at: https://www.sciencedirect.comen_ZA
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide, as it affects up to 30 % of adults in Western countries. Moreover, NAFLD is also considered an independent risk factor for cardiovascular diseases. Insulin resistance and inflammation have been identified as key factors in the pathophysiology of NAFLD. Although the mechanisms associated with the development of NAFLD remain to be fully elucidated, a complex interaction between adipokines and cytokines appear to play a crucial role in the development of this condition. Adiponectin is the most common adipokine known to be inversely linked with insulin resistance, lipid accumulation, inflammation and NAFLD. Consequently, the focus has been on the use of new therapies that may enhance hepatic expression of adiponectin downstream targets or increase the serum levels of adiponectin in the treatment NAFLD. While currently used therapies show limited efficacy in this aspect, accumulating evidence suggest that various dietary polyphenols may stimulate adiponectin levels, offering potential protection against the development of insulin resistance, inflammation and NAFLD as well as associated conditions of metabolic syndrome. As such, this review provides a better understanding of the role polyphenols play in modulating adiponectin signaling to protect against NAFLD. A brief discussion on the regulation of adiponectin during disease pathophysiology is also covered to underscore the potential protective effects of polyphenols against NAFLD. Some of the prominent polyphenols described in the manuscript include aspalathin, berberine, catechins, chlorogenic acid, curcumin, genistein, piperine, quercetin, and resveratrol.en_ZA
dc.description.versionPublisher's versionen_ZA
dc.format.extent17 pagesen_ZA
dc.identifier.citationShabalala, Samukelisiwe C. et al. 2020. The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling. Biomed Pharmacotherapy, 131:110785, doi:10.1016/j.biopha.2020.110785en_ZA
dc.identifier.issn0753-3322 (print)en_ZA
dc.identifier.otherdoi:10.1016/j.biopha.2020.110785en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/125174en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherElsevier Masson SASen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectFat necrosis -- Pathogenesisen_ZA
dc.subjectLipids -- Metabolismen_ZA
dc.subjectInsulin resistanceen_ZA
dc.subjectLiver -- Pathophysiologyen_ZA
dc.subjectNon-alcoholic fatty liver diseasesen_ZA
dc.subjectPolyphenolsen_ZA
dc.titleThe effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signalingen_ZA
dc.typeArticleen_ZA
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