Aspalathin-rich green rooibos extract lowers LDL-cholesterol and oxidative status in high-fat diet-induced diabetic vervet monkeys

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dc.contributor.authorOrlando, Patricken_ZA
dc.contributor.authorChellan, Nireshnien_ZA
dc.contributor.authorLouw, Johanen_ZA
dc.contributor.authorTiano, Lucaen_ZA
dc.contributor.authorCirilli, Ileniaen_ZA
dc.contributor.authorDludla, Phiwayinkosien_ZA
dc.contributor.authorJoubert, Elizabethen_ZA
dc.contributor.authorMuller, Christo J. F.en_ZA
dc.date.accessioned2021-10-12T14:14:01Z
dc.date.available2021-10-12T14:14:01Z
dc.date.issued2019-05-02
dc.descriptionCITATION: Orlando P. et al. 2019. Aspalathin-Rich Green Rooibos Extract Lowers LDL-Cholesterol and Oxidative Status in High-Fat Diet-Induced Diabetic Vervet Monkeys. Molecules, 24(9). doi:10.3390/molecules24091713
dc.descriptionThe original publication is available at https://www.mdpi.com/journal/molecules
dc.description.abstractType 2 diabetic patients possess a two to four-fold-increased risk for cardiovascular diseases (CVD). Hyperglycemia, oxidative stress associated with endothelial dysfunction and dyslipidemia are regarded as pro-atherogenic mechanisms of CVD. In this study, high-fat diet-induced diabetic and non-diabetic vervet monkeys were treated with 90 mg/kg of aspalathin-rich green rooibos extract (Afriplex GRT) for 28 days, followed by a 1-month wash-out period. Supplementation showed improvements in both the intravenous glucose tolerance test (IVGTT) glycemic area under curve (AUC) and total cholesterol (due to a decrease of the low-density lipoprotein [LDL]) values in diabetics, while non-diabetic monkeys benefited from an increase in high-density lipoprotein (HDL) levels. No variation of plasma coenzyme Q10 (CoQ10) were found, suggesting that the LDL-lowering effect of Afriplex GRT could be related to its ability to modulate the mevalonate pathway differently from statins. Concerning the plasma oxidative status, a decrease in percentage of oxidized CoQ10 and circulating oxidized LDL (ox-LDL) levels after supplementation was observed in diabetics. Finally, the direct correlation between the amount of oxidized LDL and total LDL concentration, and the inverse correlation between ox-LDL and plasma CoQ10 levels, detected in the diabetic monkeys highlighted the potential cardiovascular protective role of green rooibos extract. Taken together, these findings suggest that Afriplex GRT could counteract hyperglycemia, oxidative stress and dyslipidemia, thereby lowering fundamental cardiovascular risk factors associated with diabetes.en_ZA
dc.description.sponsorshipNational Research Foundation
dc.description.sponsorshipItalian Ministry of Foreign Affairs
dc.description.urihttps://www.mdpi.com/1420-3049/24/9/1713
dc.description.versionPublisher’s version
dc.format.extent19 pages
dc.identifier.citationOrlando P. et al. 2019. Aspalathin-Rich Green Rooibos Extract Lowers LDL-Cholesterol and Oxidative Status in High-Fat Diet-Induced Diabetic Vervet Monkeys. Molecules, 24(9). doi:10.3390/molecules24091713
dc.identifier.issn1420-3049 (online)
dc.identifier.otherdoi:10.3390/molecules24091713
dc.identifier.urihttp://hdl.handle.net/10019.1/123215
dc.language.isoen_ZAen_ZA
dc.rights.holderAuthors retain rights
dc.subjectType 2 diabetes -- Patientsen_ZA
dc.subjectCardiovascular diseases -- Risk factorsen_ZA
dc.subjectAntidiabetic activityen_ZA
dc.subjectAspalathin-enriched green rooibos extracten_ZA
dc.subjectCoenzyme Q10en_ZA
dc.subjectNon-insulin-dependent diabetes -- Alternative treatmenten_ZA
dc.titleAspalathin-rich green rooibos extract lowers LDL-cholesterol and oxidative status in high-fat diet-induced diabetic vervet monkeysen_ZA
dc.typeArticleen_ZA
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