In vitro analysis of the combinatory effects of novel aminonaphthoquinone derivatives and curcumin on breast cancer progression
dc.contributor.author | Pereira, Melanie C. | en_ZA |
dc.contributor.author | Mohammed, Raushaan | en_ZA |
dc.contributor.author | Van Otterlo, Willem A. L. | en_ZA |
dc.contributor.author | De Koning, Charles B. | en_ZA |
dc.contributor.author | Davids, Hajierah | en_ZA |
dc.date.accessioned | 2022-04-29T07:37:23Z | |
dc.date.available | 2022-04-29T07:37:23Z | |
dc.date.issued | 2020-01 | |
dc.description | CITATION: Pereira, Melanie C. et al. 2020. In vitro analysis of the combinatory effects of novel aminonaphthoquinone derivatives and curcumin on breast cancer progression. Anticancer Research, 40(1):229-238, doi:10.21873/anticanres.13944. | en_ZA |
dc.description | The original publication is available at: https://pubmed.ncbi.nlm.nih.gov | |
dc.description.abstract | Background/aim: We previously reported the potential of aminonaphthoquinone derivatives as therapeutic agents against breast and other oestrogen-responsive tumours when combined with curcumin. This study aimed at screening of novel aminonaphthoquinone derivatives (Rau 008, Rau 010, Rau 015 and Rau 018) combined with curcumin for cytotoxic, anti-angiogenic and anti-metastatic effects on MCF-7 and MDA-MB-231 breast cancer cells. Materials and methods: Cytotoxic and anti-angiogenic effects were analysed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and enzyme-linked immunosorbent assay; while anti-metastatic effects were measured using adhesion assay, Boyden chambers and Matrigel. Results: Curcumin combined with Rau 008 elicited marked cytotoxic effects in MCF-7 cells compared with the individual treatments, whereas when it was combined with Rau 015 and with Rau 018, it displayed similar effects in MDA-MB-231 cells. The anti-angiogenic effect of Rau 015 plus curcumin in MCF-7 cells and Rau 018 plus curcumin in MDA-MB-231 cells was more effective than individual treatments, while the metastatic capability of MDA-MB-231 cells was significantly reduced after treatment with the aminonaphthoquinone-curcumin combinations. Conclusion: Aminonaphthoquinones may offer significant promise as therapeutic agents against breast cancer, particularly when combined with curcumin. | en_ZA |
dc.description.version | Publisher's version | |
dc.format.extent | 10 pages | en_ZA |
dc.identifier.citation | Pereira, Melanie C. et al. 2020. In vitro analysis of the combinatory effects of novel aminonaphthoquinone derivatives and curcumin on breast cancer progression. Anticancer Research, 40(1):229-238, doi:10.21873/anticanres.13944 | en_ZA |
dc.identifier.other | doi:10.21873/anticanres.13944 | |
dc.identifier.uri | http://hdl.handle.net/10019.1/124485 | |
dc.language.iso | en_ZA | en_ZA |
dc.publisher | International Institute of Anticancer Research | en_ZA |
dc.rights.holder | Authors retain copyright | en_ZA |
dc.subject | Aminonaphthoquinone | en_ZA |
dc.subject | Angiogenic proteins | en_ZA |
dc.subject | Metastatic cancer | en_ZA |
dc.subject | Curcumin | en_ZA |
dc.subject | Anticancer antibiotics | en_ZA |
dc.subject | Cytotoxic antibiotics | en_ZA |
dc.title | In vitro analysis of the combinatory effects of novel aminonaphthoquinone derivatives and curcumin on breast cancer progression | en_ZA |
dc.type | Article | en_ZA |