An 8-year retrospective study of adult and paediatric Burkitt’s lymphoma at Tygerberg Hospital, South Africa

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dc.contributor.authorMusekwa, Ernesten_ZA
dc.contributor.authorChapanduka, Zivanai C.en_ZA
dc.contributor.authorBassa, Fatimaen_ZA
dc.contributor.authorKruger, Marianaen_ZA
dc.date.accessioned2020-05-17T04:44:01Z
dc.date.available2020-05-17T04:44:01Z
dc.date.issued2020-04-30
dc.descriptionCITATION: Musekwa, E. et al. 2020. An 8-year retrospective study of adult and paediatric Burkitt’s lymphoma at Tygerberg Hospital, South Africa. South African Journal of Oncology, 4:a93, doi:10.4102/sajo.v4i0.93.
dc.descriptionThe original publication is available at https://sajo.org.za
dc.description.abstractBackground: Burkitt lymphoma(BL) is a high grade non-Hodgkin lymphoma, which may be underdiagnosed in South Africa, due to a high burden of infectious diseases such as HIV and TB which may present with similar clinical features. Aim: To describe demographics and clinico-pathological characteristics of patients diagnosed with BL. Setting: Tygerberg Hospital (TBH), South Africa between 2007-2014. Methods: We performed a retrospective descriptive and survival analysis of patients diagnosed with BL at TBH between 01 January 2007 and 31 December 2014 with at least 24-month follow-up. Data was collected from the Tygerberg Lymphoma Study Group database and the South African Children Cancer Study Group Tumour Registry. Results: There were 73 patients with BL, of whom 68 were admitted to TBH and whose data was further analysed. The majority of patients were adults (74%). There was a female predominance in adults and a male predominance in children (p = 0.002). Various regimens were used in adults while a single treatment protocol was used in children. The proportion of patients with HIV and advanced BL was higher in adults than in children. The 2-year overall survival of the treatment group was 45%. The outcome of patients with BL in adults (34%) was poorer than that of children (69%) (p = 0.022). HIV negative patients had a non-significant survival advantage (57%) over HIV positive patients with 41% 2-year overall survival (p = 0.2876). Conclusion: This study demonstrates a better cure rate in children treated for BL compared to adults, with HIV-infection being a risk factor for poor outcome.en_ZA
dc.description.urihttps://sajo.org.za/index.php/sajo/article/view/93
dc.description.versionPublisher's version
dc.format.extent8 pagesen_ZA
dc.identifier.citationMusekwa, E. et al. 2020. An 8-year retrospective study of adult and paediatric Burkitt’s lymphoma at Tygerberg Hospital, South Africa. South African Journal of Oncology, 4:a93, doi:10.4102/sajo.v4i0.93.
dc.identifier.issn2523-0646 (online)
dc.identifier.issn2518-8704 (print)
dc.identifier.otherdoi:10.4102/sajo.v4i0.93
dc.identifier.urihttp://hdl.handle.net/10019.1/108566
dc.language.isoen_ZAen_ZA
dc.publisherAOSISen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectChildren -- Disease -- Epidemiologyen_ZA
dc.subjectBurkitt's lymphomaen_ZA
dc.subjectLymphomasen_ZA
dc.subjectAdults -- HIV (Virus) -- Treatmenten_ZA
dc.subjectAdults -- Tuberculosis -- Treatmenten_ZA
dc.titleAn 8-year retrospective study of adult and paediatric Burkitt’s lymphoma at Tygerberg Hospital, South Africaen_ZA
dc.typeArticleen_ZA
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