Anxiety : an overlooked confounder in the characterisation of chronic stress-related conditions?

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dc.contributor.authorViljoen, Moneten_ZA
dc.contributor.authorBenecke, Rohan M.en_ZA
dc.contributor.authorMartin, Lindien_ZA
dc.contributor.authorAdams, Rozanne C. M.en_ZA
dc.contributor.authorSeedat, Sorayaen_ZA
dc.contributor.authorSmith, Carineen_ZA
dc.date.accessioned2021-08-16T12:55:20Z
dc.date.available2021-08-16T12:55:20Z
dc.date.issued2020-04-16
dc.descriptionCITATION: Viljoen, M., et al. 2020. Anxiety : an overlooked confounder in the characterisation of chronic stress-related conditions?. PLoS ONE, 15(4):e0230053, doi:10.1371/journal.pone.0230053.
dc.descriptionThe original publication is available at https://journals.plos.org/plosone/
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund
dc.description.abstractAlthough anxiety disorders are among the most prevalent of psychiatric disorders, childhood trauma-related studies seldom consider anxiety proneness as distinct aetiological contributor. We aimed to distinguish between trauma- and anxiety-associated physiological profiles. South African adolescent volunteers were categorised for trauma exposure (CTQ, mean score 39±11) and anxiety proneness (AP)(CASI, mean score 37±7, STAI-T, mean score 41±8). Circulating hormone and leukocyte glucocorticoid receptor levels, as well as leukocyte functional capacity, were assessed. AP was associated with lower DHEAs (P<0.05) and higher leukocyte GR expression (P<0.05). DHEAs was also negatively correlated with anxiety sensitivity (CASI, P<0.05). In conclusion, AP may have more predictive power than trauma in terms of health profile. Increased glucocorticoid sensitivity previously reported after trauma, may be a unique function of anxiety and not trauma exposure per se. DHEAs concentration was identified as potentially useful marker for monitoring progressive changes in HPA-axis sensitivity and correlated with psychological measures of anxiety.en_ZA
dc.description.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230053#abstract0
dc.description.versionPublisher's version
dc.format.extent16 pages
dc.identifier.citationViljoen, M., et al. 2020. Anxiety : an overlooked confounder in the characterisation of chronic stress-related conditions?. PLoS ONE, 15(4):e0230053, doi:10.1371/journal.pone.0230053
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0230053
dc.identifier.urihttp://hdl.handle.net/10019.1/110855
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Science
dc.rights.holderAuthors retain copyright
dc.subjectAnxietyen_ZA
dc.subjectAnxiety in adolescence -- Psychological aspectsen_ZA
dc.subjectTraumaen_ZA
dc.subjectGlucocorticoids -- Receptorsen_ZA
dc.subjectChronic stressen_ZA
dc.titleAnxiety : an overlooked confounder in the characterisation of chronic stress-related conditions?en_ZA
dc.typeArticleen_ZA
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