A diffusion tensor imaging and neuropsychological study of prospective memory impairment in South African HIV positive individuals

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dc.contributor.authorJacqueline H.
dc.contributor.authorJenny W.-T.
dc.contributor.authorJean-Paul F.
dc.contributor.authorBruce S.
dc.contributor.authorRobert P.
dc.contributor.authorKevin T.
dc.contributor.authorDan S.
dc.contributor.authorJohn J.
dc.date.accessioned2012-08-17T12:36:35Z
dc.date.available2012-08-17T12:36:35Z
dc.date.issued2012
dc.description.abstractHIV-associated prospective memory (ProM) impairment has emerged, in earlier studies as a significant predictor of medication management and independence in activities of daily living. The relationship between ProM and white matter integrity in HIV has not previously been investigated. Participants, including 128 HIV-infected individuals and 32 healthy controls, were assessed using a comprehensive neuropsychological evaluation and both objective and subjective measures of ProM. Diffusion tensor imaging (DTI) was utilized to investigate the relationship of white matter integrity to ProM in a randomly selected subsample of 40 HIV positive subjects, using a whole brain voxel-based approach to define fractional anisotrophy (FA) and mean diffusion (MD). Total prospective memory was significantly poorer in the HIV positive group when compared with healthy controls (p00.023). Timebased ProM was poorer in the HIV group compared to healthy controls both without prompts (p00.001) and with prompts (p00.001). Poor Total ProM score correlated with performance on neuropsychological tests of executive functioning, information processing speed, learning, and working memory (p<0.05). Those HIV positive participants with poor ProM had significantly decreased FA in the regions of superior corona radiata (p00.0035), the corpus collosum (p00.006) and the cingulum (p00.0033) when compared to those who were HIV positive with good ProM. This study reinforces the importance of ProM assessment in HIV. © Springer Science+Business Media, LLC 2012.
dc.identifier.citationMetabolic Brain Disease
dc.identifier.citation27
dc.identifier.citation3
dc.identifier.citation289
dc.identifier.citation297
dc.identifier.issn8857490
dc.identifier.other10.1007/s11011-012-9311-0
dc.identifier.urihttp://hdl.handle.net/10019.1/49278
dc.subjectDementia
dc.subjectExecutive function
dc.subjectHIV/Aids
dc.subjectLearning and memory
dc.subjectMild cognitive impairment
dc.subjectNeuroimaging (functional)
dc.titleA diffusion tensor imaging and neuropsychological study of prospective memory impairment in South African HIV positive individuals
dc.typeArticle
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