PROVE—Pre-Eclampsia Obstetric Adverse Events: Establishment of a Biobank and Database for Pre-Eclampsia

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dc.contributor.authorBergman, Linaen_ZA
dc.contributor.authorBergman, Karlen_ZA
dc.contributor.authorLangenegger, Eduarden_ZA
dc.contributor.authorMoodley, Ashleyen_ZA
dc.contributor.authorGriffith-Richards, Stephanieen_ZA
dc.contributor.authorWikström, Johanen_ZA
dc.contributor.authorHall, Daviden_ZA
dc.contributor.authorJoubert, Lloyden_ZA
dc.contributor.authorHerbst, Philipen_ZA
dc.contributor.authorSchell, Sonjaen_ZA
dc.contributor.authorVan Veen, Teelkienen_ZA
dc.contributor.authorBelfort, Michaelen_ZA
dc.contributor.authorTong, Stephen Y. C.en_ZA
dc.contributor.authorWalker, Susanen_ZA
dc.contributor.authorHastie, Roxanneen_ZA
dc.contributor.authorCluver, Catherineen_ZA
dc.date.accessioned2023-05-11T13:00:18Zen_ZA
dc.date.available2023-05-11T13:00:18Zen_ZA
dc.date.issued2021-04en_ZA
dc.descriptionCITATION: Bergman, L.; Bergman, K.; Langenegger, E.; Moodley, A.; Griffith-Richards, S.;Wikström, J.; Hall, D.; Joubert, L.; Herbst, P.; Schell, S.; et al. PROVE—Pre-Eclampsia Obstetric Adverse Events: Establishment of a Biobank and Database for Pre-Eclampsia. Cells 2021, 10, 959. doi.10.3390/cells10040959en_ZA
dc.descriptionThe original publication is available at: mdpi.comen_ZA
dc.description.abstractPre-eclampsia is a leading cause of maternal and perinatal morbidity and mortality. The burden of disease lies mainly in low-middle income countries. The aim of this project is to establish a pre-eclampsia biobank in South Africa to facilitate research in the field of pre-eclampsia with a focus on phenotyping severe disease.The approach of our biobank is to collect biological specimens, detailed clinical data, tests, and biophysical examinations, including magnetic resonance imaging (MRI) of the brain, MRI of the heart, transcranial Doppler, echocardiography, and cognitive function tests.Women diagnosed with pre-eclampsia and normotensive controls are enrolled in the biobank at admission to Tygerberg University Hospital (Cape Town, South Africa). Biological samples and clinical data are collected at inclusion/delivery and during the hospital stay. Special investigations as per above are performed in a subset of women. After two months, women are followed up by telephonic interviews. This project aims to establish a biobank and database for severe organ complications of pre-eclampsia in a low-middle income country where the incidence of pre-eclampsia with organ complications is high. The study integrates different methods to investigate pre-eclampsia, focusing on improved understanding of pathophysiology, prediction of organ complications, and potentially future drug evaluation and discovery.en_ZA
dc.description.versionPublisher’s versionen_ZA
dc.format.extent12 pagesen_ZA
dc.identifier.citationBergman, L.; Bergman, K.; Langenegger, E.; Moodley, A.; Griffith-Richards, S.;Wikström, J.; Hall, D.; Joubert, L.; Herbst, P.; Schell, S.; et al. PROVE—Pre-Eclampsia Obstetric Adverse Events: Establishment of a Biobank and Database for Pre-Eclampsia. Cells 2021, 10, 959. doi.10.3390/cells10040959en_ZA
dc.identifier.issn2073-4409 (online)en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/126903en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherMDPIen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectPreeclampsiaen_ZA
dc.subjectEclampsiaen_ZA
dc.subjectPerinatal deathen_ZA
dc.subjectBiobanksen_ZA
dc.titlePROVE—Pre-Eclampsia Obstetric Adverse Events: Establishment of a Biobank and Database for Pre-Eclampsiaen_ZA
dc.typeArticleen_ZA
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