Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors

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dc.contributor.authorChakravorty, Santanuen_ZA
dc.contributor.authorKlein, Hanna F.en_ZA
dc.contributor.authorHodson, Luke E.en_ZA
dc.contributor.authorRabillier, Matthiasen_ZA
dc.contributor.authorFang, Zhizhouen_ZA
dc.contributor.authorRichters, Andreen_ZA
dc.contributor.authorPelly, Stephen C.en_ZA
dc.contributor.authorRauh, Danielen_ZA
dc.contributor.authorVan Otterlo, Willem A. L.en_ZA
dc.date.accessioned2016-01-14T12:47:59Z
dc.date.available2016-01-14T12:47:59Z
dc.date.issued2014-03
dc.descriptionPlease cite as follows: Chakravorty, S. et al. 2014. Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors. South African Journal of Chemistry, 67:71–79.en_ZA
dc.descriptionThe original publication is available at http://www.journals.co.za/sajchemen_ZA
dc.description.abstractSubstituted anthranilic acid and piperazines were used as building blocks to prepare two libraries of compounds, with the aim being that they would exhibit biochemical activity as small molecule kinase inhibitors. The synthesized anthranilamidepiperazine compounds were subsequently tested against a panel of kinases including EGFR, Abl, Akt and Aurora B.en_ZA
dc.description.urihttp://www.scielo.org.za/scielo.php?script=sci_abstract&pid=S0379-43502014000100012&lng=en&nrm=iso&tlng=en
dc.description.versionPublisher's versionen_ZA
dc.format.extent17 pagesen_ZA
dc.identifier.citationChakravorty, S. et al. 2014. Synthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitors. South African Journal of Chemistry, 67:71–79.en_ZA
dc.identifier.issn1996-840X (online)
dc.identifier.issn0379-4350 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/98171
dc.language.isoen_ZAen_ZA
dc.publisherSouth African Chemical Instituteen_ZA
dc.rights.holderSouth African Chemical Instituteen_ZA
dc.subjectMolecule kinase inhibitorsen_ZA
dc.subjectAnthranilic aciden_ZA
dc.subjectPiperazinesen_ZA
dc.titleSynthesis of novel piperazine-linked anthranilic acids as potential small molecule kinase inhibitorsen_ZA
dc.typeArticleen_ZA
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