Endocrine responses after thyrotrophin-releasing hormone stimulation and dexamethasone suppression tests in the major depressive syndrome

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dc.contributor.authorAalbers, C.en_ZA
dc.contributor.authorTaljaard, J. J. F.en_ZA
dc.contributor.authorGagiano, C. A.en_ZA
dc.date.accessioned2011-03-18T14:59:39Z
dc.date.available2011-03-18T14:59:39Z
dc.date.issued1986-10
dc.descriptionCITATION: Aalbers, C., Taljaard, J.J.F. & Gagiano, C.A. 1986. Endocrine responses after thyrotrophin-releasing hormone stimulation and dexamethasone suppression tests in the major depressive syndrome. S Afr Med J, 70(4):464-468.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractThe effects of dexamethasone 1 mg on plasma cortisol levels and of thyrotrophin-releasing hormone (TRH) 200 μg on thyrotrophin (TSH), growth hormone and prolactine levels in 107 patients with a major depressive disorder (MDD) were compared with those in 87 healthy subjects. Individual hormonal responses and combinations of hormonal responses after administration of dexamethasone and TRH were evaluated as diagnostic aids for MDD by calculating sensitivity, specificity and efficiency for single and multiple hormonal abnormalities. In patients suffering from MDD, 65% of men, 74% of reproductive women and 71% of menopausal or hysterectomized (H/M) women had abnormal responses (sensitivity) to a dexamethasone suppression test (DST). When the DST and TSH responses to TRH were combined, 85% of men, 87% of reproductive women and 84% of H/M women had abnormal results. If the efficiency of the different combinations of hormone responses is calculated, a totally different picture emerges.
dc.description.versionPublisher’s version
dc.identifier.citationAalbers, C., Taljaard, J.J.F. & Gagiano, C.A. 1986. Endocrine responses after thyrotrophin-releasing hormone stimulation and dexamethasone suppression tests in the major depressive syndrome. S Afr Med J, 70(4):464-468.
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7961
dc.language.isoen
dc.publisherHealth & Medical Publishing Group
dc.rights.holderSouth African Medical Journal
dc.subjectMajor depressive disorder -- Diagnosisen_ZA
dc.subjectMajor depressive disorder -- Hormonal aspectsen_ZA
dc.subjectDexamethason -- Testingen_ZA
dc.subjectThyrotropin releasing factor -- Testingen_ZA
dc.subjectHydrocortisone -- Testingen_ZA
dc.titleEndocrine responses after thyrotrophin-releasing hormone stimulation and dexamethasone suppression tests in the major depressive syndromeen_ZA
dc.typeArticle
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