Hearing loss in patients on treatment for drug-resistant tuberculosis
Date
2012-06
Authors
Seddon, James A.
Godfrey-Faussett, Peter
Jacobs, Kayleen
Ebrahim, Adam
Hesseling, Anneke C.
Schaaf, H. Simon
Journal Title
Journal ISSN
Volume Title
Publisher
European Respiratory Society
Abstract
The treatment of drug‐resistant (DR) tuberculosis (TB) necessitates the use of second‐line injectable
anti‐TB drugs which are associated with hearing loss. Hearing loss affects communication and for
children the development of language and social skills. This article describes the pathophysiology of
hearing loss and the testing methodologies that can be employed. It is the first paper to
systematically review the literature regarding hearing loss in those treated for DR‐TB. In the studies
identified, the methodology used to test for and to classify hearing loss is inconsistent and children
and those with HIV are poorly represented. The review describes existing guidelines and suggests
management strategies when hearing loss is found. It describes the challenges of testing hearing in
the developing world contexts where the majority of patients with DR‐TB are treated. Finally it
makes the recommendation that a standardised testing methodology and classification system be
used.
Description
The original publication is available at http://erj.ersjournals.com/
Published ahead of print on 14 June 2012, as a manuscript, for the June publication. Indicated on the Website as ERJ in press the copyediting, typesetting, and proofreading, has not been performed.
Bibliography
Publication of this article was funded by the Stellenbosch University Open Access Fund.
Published ahead of print on 14 June 2012, as a manuscript, for the June publication. Indicated on the Website as ERJ in press the copyediting, typesetting, and proofreading, has not been performed.
Bibliography
Publication of this article was funded by the Stellenbosch University Open Access Fund.
Keywords
Hearing loss -- Effect of drug resistant tuberculosis on, Drug‐resistant tuberculosis, Ototoxicity
Citation
Seddon, J. A. et al. 2012. Hearing loss in patients on treatment for drug-resistant tuberculosis.. European Respiratory Journal, doi:10.1183/09031936.00044812.