Oxidatives stress and adipocyte biology : focus on therole of AGEs

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dc.contributor.authorBoyer, Florenceen_ZA
dc.contributor.authorVidot, Jennifer Barakaen_ZA
dc.contributor.authorDubourg, Alexis Guerinen_ZA
dc.contributor.authorRondeau, Philippeen_ZA
dc.contributor.authorEssop, M. Faadielen_ZA
dc.contributor.authorBourdon, Emmanuelen_ZA
dc.date.accessioned2016-11-18T09:31:01Z
dc.date.available2016-11-18T09:31:01Z
dc.date.issued2015-03
dc.descriptionCITATION: Boyer, F. et al. 2015. Oxidatives stress and adipocyte biology : focus on therole of AGEs, Oxidative Medicine and Cellular Longevity, Article ID 534873, doi:10.1155/2015/534873.
dc.descriptionThe original publication is available at https://www.hindawi.com/journals/omcl
dc.description.abstractDiabetes is a major health problem that is usually associated with obesity, together with hyperglycemia and increased advanced glycation endproducts (AGEs) formation. Elevated AGEs elicit severe downstream consequences via their binding to receptors of AGEs (RAGE). This includes oxidative stress and oxidative modifications of biological compounds together with heightened inflammation. For example, albumin (major circulating protein) undergoes increased glycoxidation with diabetes and may represent an important biomarker for monitoring diabetic pathophysiology. Despite the central role of adipose tissue in many physiologic/pathologic processes, recognition of the effects of greater AGEs formation in this tissue is quite recent within the obesity/diabetes context. This review provides a brief background of AGEs formation and adipose tissue biology and thereafter discusses the impact of AGEs-adipocyte interactions in pathology progression. Novel data are included showing how AGEs (especially glycated albumin) may be involved in hyperglycemia-induced oxidative damage in adipocytes and its potential links to diabetes progression.en_ZA
dc.description.urihttps://www.hindawi.com/journals/omcl/2015/534873/
dc.description.versionPublisher's version
dc.format.extent10 pages : illustrationsen_ZA
dc.identifier.citationBoyer, F. et al. 2015. Oxidatives stress and adipocyte biology : focus on therole of AGEs, Oxidative Medicine and Cellular Longevity, Article ID 534873, doi:10.1155/2015/534873.
dc.identifier.issn1942-0994 (online)
dc.identifier.issn1942-0900 (print)
dc.identifier.otherdoi:10.1155/2015/534873
dc.identifier.urihttp://hdl.handle.net/10019.1/99876
dc.language.isoen_ZAen_ZA
dc.publisherHindawi
dc.rights.holderAuthors retain copyright
dc.subjectDiabetesen_ZA
dc.subjectOxidative stressen_ZA
dc.subjectAdvanced glycation endproductsen_ZA
dc.subjectAdipocyte biologyen_ZA
dc.subjectObesityen_ZA
dc.subjectHyperglycemiaen_ZA
dc.titleOxidatives stress and adipocyte biology : focus on therole of AGEsen_ZA
dc.typeArticleen_ZA
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