Comparison of mental health screening tools for detecting antenatal depression and anxiety disorders in South African women
Date
2018-04-18
Journal Title
Journal ISSN
Volume Title
Publisher
Public Library of Science
Abstract
Background
Antenatal depression and anxiety disorders are highly prevalent in low and middle-income countries. Screening of pregnant women in primary care antenatal settings provides an opportunity for entry to care, but data are needed on the performance of different screening tools. We compared five widely-used questionnaires in a sample of pregnant women in urban South Africa.
Method
Pregnant women attending a primary care antenatal clinic were administered five tools by trained research assistants: the Edinburgh Postnatal Depression Scale (EPDS), the Patient Health Questionnaire (PHQ-9), the Kessler Psychological Distress scale (K10) and a shortened 6-item version (K6), the Whooley questions and the two-item Generalised Anxiety Disorder scale (GAD-2). Following this, a registered mental health counsellor administered the MINI Plus, a structured clinical diagnostic interview. The Area Under the Curve (AUC) from Receiver Operator Characteristic curve analysis was used to summarise screening test performance and Cronbach’s α used to assess internal consistency.
Results
Of 376 participants, 32% were diagnosed with either MDE and/or anxiety disorders. All five questionnaires demonstrated moderate to high performance (AUC = 0.78–0.85). The EPDS was the best performing instrument for detecting MDE and the K10 and K6 for anxiety disorder. For MDE and/or anxiety disorders, the EPDS had the highest AUC (0.83). Of the short instruments, the K10 (AUC = 0.85) and the K6 (AUC = 0.85) performed the best, with the K6 showing good balance between sensitivity (74%) and specificity (85%) and a good positive predictive value (70%). The Whooley questions (AUC = 0.81) were the best performing ultra-short instrument. Internal consistency ranged from good to acceptable (α = 0.89–0.71). However, the PPV of the questionnaires compared with the diagnostic interview, ranged from 54% to 71% at the optimal cut-off scores.
Conclusions
Universal screening for case identification of antenatal depression and anxiety disorders in low-resource settings can be conducted with a number of commonly used screening instruments. Short and ultra-short screening instruments such as the K6 and the Whooley questions may be feasible and acceptable for use in these settings.
Description
CITATION: Van Heyningen, T., et al. 2018. Comparison of mental health screening tools for detecting antenatal depression and anxiety disorders in South African women. PLoS ONE, 13(4):e0193697, doi:10.1371/journal.pone.0193697.
The original publication is available at https://journals.plos.org/plosone/
The original publication is available at https://journals.plos.org/plosone/
Keywords
Depression and anxiety disorders, Perinatal -- Mental health, Anxiety disorder, Medical screening -- Tools
Citation
Van Heyningen, T., et al. 2018. Comparison of mental health screening tools for detecting antenatal depression and anxiety disorders in South African women. PLoS ONE, 13(4):e0193697, doi:10.1371/journal.pone.0193697