The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance
Date
2019-12-27
Journal Title
Journal ISSN
Volume Title
Publisher
BMC (part of Springer Nature)
Abstract
Objective: Gene–environment interactions contribute to the development of HIV-associated neurocognitive disorders. We examined whether childhood trauma, apolipoprotein E isoforms and viral protein R (Vpr) variants were associated with change in cognitive performance. Seventy-three seropositive women completed neuropsychological assessments at baseline and 1-year follow-up. We conducted genetic analyses using DNA obtained from blood and calculated risk scores based on Vpr amino acid 37, 41 and 55 variants that were previously associated with cognitive performance.
Results: Global cognitive scores declined significantly over the 1-year study period (p = 0.029). A reduction in global
cognitive scores was associated with childhood trauma experience (p = 0.039).
Description
CITATION: Womersley, J. S., et al. 2019. The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance. BMC Research Notes, 12:828, doi:10.1186/s13104-019-4869-9.
The original publication is available at https://bmcresnotes.biomedcentral.com
The original publication is available at https://bmcresnotes.biomedcentral.com
Keywords
Apolipoprotein E, Early life trauma, Viral protein R, Cognitive performance
Citation
Womersley, J. S., et al. 2019. The effect of childhood trauma, ApoE genotype and HIV-1 viral protein R variants on change in cognitive performance. BMC Research Notes, 12:828, doi:10.1186/s13104-019-4869-9