Rheumatoid cachexia : the underappreciated role of myoblast, macrophage and fibroblast interplay in the skeletal muscle niche
Date
2021-03-03
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central
Abstract
ENGLISH ABSTRACT: Although rheumatoid arthritis affects 1% of the global population, the role of rheumatoid cachexia, which occurs
in up to a third of patients, is relatively neglected as research focus, despite its significant contribution to decreased
quality of life in patients. A better understanding of the cellular and molecular processes involved in rheumatoid
cachexia, as well as its potential treatment, is dependent on elucidation of the intricate interactions of the cells
involved, such as myoblasts, fibroblasts and macrophages. Persistent RA-associated inflammation results in a relative
depletion of the capacity for regeneration and repair in the satellite cell niche. The repair that does proceed is suboptimal
due to dysregulated communication from the other cellular role players in this multi-cellular environment. This
includes the incomplete switch in macrophage phenotype resulting in a lingering pro-inflammatory state within the
tissues, as well as fibroblast-associated dysregulation of the dynamic control of the extracellular matrix. Additional to
this endogenous dysregulation, some treatment strategies for RA may exacerbate muscle wasting and no multi-cell
investigation has been done in this context. This review summarizes the most recent literature characterising clinical
RA cachexia and links these features to the roles of and complex communication between multiple cellular contributors
in the muscle niche, highlighting the importance of a targeted approach to therapeutic intervention.
Description
CITATION: Ollewagen, T., et al. 2021. Rheumatoid cachexia : the underappreciated role of myoblast, macrophage and fibroblast interplay in the skeletal muscle niche. Journal of Biomedical Science, 28:15, doi:10.1186/s12929-021-00714-w.
The original publication is available at https://jbiomedsci.biomedcentral.com
The original publication is available at https://jbiomedsci.biomedcentral.com
Keywords
Intracellular communication, Cachexia, Rheumatoid factor, Macrophages, Fibroblast growth factors, Extracellular matrix
Citation
Ollewagen, T., et al. 2021. Rheumatoid cachexia : the underappreciated role of myoblast, macrophage and fibroblast interplay in the skeletal muscle niche. Journal of Biomedical Science, 28:15, doi:10.1186/s12929-021-00714-w