Patterning of individual variability in neurocognitive health among South African women exposed to childhood maltreatment

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dc.contributor.authorDenckla, Christy A.en_ZA
dc.contributor.authorLee, Sun Yeopen_ZA
dc.contributor.authorKim, Rocklien_ZA
dc.contributor.authorSpies, Georginaen_ZA
dc.contributor.authorVasterling, Jennifer J.en_ZA
dc.contributor.authorSubramanian, S. V.en_ZA
dc.contributor.authorSeedat, Sorayaen_ZA
dc.date.accessioned2023-04-06T13:33:31Zen_ZA
dc.date.available2023-04-06T13:33:31Zen_ZA
dc.date.issued2021-03en_ZA
dc.descriptionCITATION: Denckla, C. A. et al. 2021. Patterning of individual variability in neurocognitive health among South African women exposed to childhood maltreatment. Scientific Reports, 11:6669, doi:10.1038/s41598-021-85979-9.en_ZA
dc.descriptionThe original publication is available at https://www.nature.comen_ZA
dc.description.abstractThere are individual differences in health outcomes following exposure to childhood maltreatment, yet constant individual variance is often assumed in analyses. Among 286 Black, South African women, the association between childhood maltreatment and neurocognitive health, defined here as neurocognitive performance (NP), was first estimated assuming constant variance. Then, without assuming constant variance, we applied Goldstein’s method (Encyclopedia of statistics in behavioral science, Wiley, 2005) to model “complex level-1 variation” in NP as a function of childhood maltreatment. Mean performance in some tests of information processing speed (Digit-symbol, Stroop Word, and Stroop Color) lowered with increasing severity of childhood maltreatment, without evidence of significant individual variation. Conversely, we found significant individual variation by severity of childhood maltreatment in tests of information processing speed (Trail Making Test) and executive function (Color Trails 2 and Stroop Color-Word), in the absence of mean differences. Exploratory results suggest that the presence of individual-level heterogeneity in neurocognitive performance among women exposed to childhood maltreatment warrants further exploration. The methods presented here may be used in a person-centered framework to better understand vulnerability to the toxic neurocognitive effects of childhood maltreatment at the individual level, ultimately informing personalized prevention and treatment.en_ZA
dc.description.urihttps://www.nature.com/articles/s41598-021-85979-9en_ZA
dc.description.versionPublisher's versionen_ZA
dc.format.extent11 pagesen_ZA
dc.identifier.citationDenckla, C. A. et al. 2021. Patterning of individual variability in neurocognitive health among South African women exposed to childhood maltreatment. Scientific Reports, 11:6669, doi:10.1038/s41598-021-85979-9.en_ZA
dc.identifier.issn2045-2322 (online)en_ZA
dc.identifier.otherdoi:10.1038/s41598-021-85979-9en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/126778en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherNatureen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectAdult child abuse victims -- Mental healthen_ZA
dc.subjectWomen -- Mental healthen_ZA
dc.subjectGenerations, Alternatingen_ZA
dc.subjectMental health -- South Africaen_ZA
dc.subjectNeurocognitive performanceen_ZA
dc.titlePatterning of individual variability in neurocognitive health among South African women exposed to childhood maltreatmenten_ZA
dc.typeArticleen_ZA
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