MDR/XDR-TB management of patients and contacts : challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

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dc.contributor.authorMigliori, Giovanni Battistaen_ZA
dc.contributor.authorTiberi, Simonen_ZA
dc.contributor.authorZumla, Alimuddinen_ZA
dc.contributor.authorPetersen, Eskilden_ZA
dc.contributor.authorChakaya, Jeremiah Muhwaen_ZA
dc.contributor.authorWejse, Christianen_ZA
dc.contributor.authorTorrico, Marcela Munozen_ZA
dc.contributor.authorDuarte, Raquelen_ZA
dc.contributor.authorAlffenaar, Jan Willemen_ZA
dc.contributor.authorSchaaf, H. Simonen_ZA
dc.contributor.authorMarais, Ben J.en_ZA
dc.contributor.authorCirillo, Daniela Mariaen_ZA
dc.contributor.authorAlagna, Riccardoen_ZA
dc.contributor.authorRendon, Adrianen_ZA
dc.contributor.authorPontali, Emanueleen_ZA
dc.contributor.authorPiubello, Albertoen_ZA
dc.contributor.authorFigueroa, Joseen_ZA
dc.contributor.authorFerlazzo, Gabriellaen_ZA
dc.contributor.authorGarcía-Basteiro, Albertoen_ZA
dc.contributor.authorCentis, Rosellaen_ZA
dc.contributor.authorVisca, Dinaen_ZA
dc.contributor.authorD’Ambrosio, Liaen_ZA
dc.contributor.authorSotgiu, Giovannien_ZA
dc.date.accessioned2022-09-13T13:01:29Zen_ZA
dc.date.available2022-09-13T13:01:29Zen_ZA
dc.date.issued2020-03en_ZA
dc.descriptionCITATION: Migliori, G. B. et al. 2020. MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network. International Journal of Infectious Diseases, 92:S15-S25. doi:10.1016/j.ijid.2020.01.042en_ZA
dc.descriptionThe original publication is available at https://www.journals.elsevier.com/international-journal-of-infectious-diseasesen_ZA
dc.description.abstractThe continuous flow of new research articles on MDR-TB diagnosis, treatment, prevention and rehabilitation requires frequent update of existing guidelines. This review is aimed at providing clinicians and public health staff with an updated and easy-to-consult document arising from consensus of Global Tuberculosis Network (GTN) experts. The core published documents and guidelines have been reviewed, including the recently published MDR-TB WHO rapid advice and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in children) are discussed. Furthermore, the review comprehensively describes the latest information on contact tracing and LTBI management in MDR-TB contacts, while providing guidance on post-treatment functional evaluation and rehabilitation of TB sequelae, infection control and other public health priorities.en_ZA
dc.description.urihttps://www.journals.elsevier.com/international-journal-of-infectious-diseasesen_ZA
dc.description.versionPublishers versionen_ZA
dc.format.extent11 pagesen_ZA
dc.identifier.citationMigliori, G. B. et al. 2020. MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network. International Journal of Infectious Diseases, 92:S15-S25. doi:10.1016/j.ijid.2020.01.042en_ZA
dc.identifier.issn1878-3511 (online)en_ZA
dc.identifier.issn1201-9712 (print)en_ZA
dc.identifier.otherdoi:10.1016/j.ijid.2020.01.042en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/125715en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherElsevieren_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectMDR-TBen_ZA
dc.subjectXDR-TBen_ZA
dc.subjectDiagnosisen_ZA
dc.subjectTreatmenten_ZA
dc.subjectPreventionen_ZA
dc.subjectRehabilitation of sequelaeen_ZA
dc.titleMDR/XDR-TB management of patients and contacts : challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Networken_ZA
dc.typeArticleen_ZA
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