Clinical relevance of nontuberculous mycobacteria isolated from sputum in a gold mining workforce in South Africa : an observational, clinical study

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dc.contributor.authorVan Halsema, Clare L.en_ZA
dc.contributor.authorChihota, Violet N.en_ZA
dc.contributor.authorGey van Pittius, Nicolaas C.en_ZA
dc.contributor.authorFielding, Katherine L.en_ZA
dc.contributor.authorLewis, James J.en_ZA
dc.contributor.authorVan Helden, Paul D.en_ZA
dc.contributor.authorChurchyard, Gavin J.en_ZA
dc.contributor.authorGrant, Alison D.en_ZA
dc.date.accessioned2016-12-21T06:50:16Z
dc.date.available2016-12-21T06:50:16Z
dc.date.issued2015
dc.descriptionCITATION: Van Halsema, C. L. et al. 2015. Clinical relevance of nontuberculous mycobacteria isolated from sputum in a gold mining workforce in South Africa : an observational, clinical study. BioMed Research International, 2015, Article ID 959107, doi:10.1155/2015/959107.en_ZA
dc.descriptionThe original publication is available at https://www.hindawi.com/journals/bmrien_ZA
dc.description.abstractBackground.The clinical relevance of nontuberculous mycobacteria (NTM), detected by liquid more than solid culture in sputum specimens from a South African mining workforce, is uncertain. We aimed to describe the current spectrum and relevance of NTMin this population. Methods. An observational study including individuals with sputum NTMisolates, recruited at workforce tuberculosis screening and routine clinics. Symptomquestionnaires were administered at the time of sputumcollection and clinical records and chest radiographs reviewed retrospectively. Results.Of 232 individuals included (228 (98%) male,median age 44 years), M. gordonae (60 individuals), M. kansasii (50), and M. aviumcomplex (MAC: 38) were the commonest species.Of 38MAC isolates, only 2 (5.3%) were from smear-positive sputum specimens and 30/38 grew in liquid but not solid culture. MAC was especially prevalent among symptomatic, HIV-positive individuals. HIV prevalence was high: 57/74 (77%) among those tested.No differences were found in probability of death or medical separation by NTM species. Conclusions. M. gordonae, M. kansasii, andMAC were the commonest NTMamong miners with suspected tuberculosis, withmostMAC fromsmear-negative specimens in liquid culture only. HIV testing and identification of key pathogenic NTM in this setting are essential to ensure optimal treatment.en_ZA
dc.description.urihttps://www.hindawi.com/journals/bmri/2015/959107/
dc.description.versionPublisher's versionen_ZA
dc.format.extent11 pages : illustrationsen_ZA
dc.identifier.citationVan Halsema, C. L. et al. 2015. Clinical relevance of nontuberculous mycobacteria isolated from sputum in a gold mining workforce in South Africa : an observational, clinical study. BioMed Research International, 2015, Article ID 959107, doi:10.1155/2015/959107.en_ZA
dc.identifier.issn2314-6141 (online)
dc.identifier.otherdoi:10.1155/2015/959107
dc.identifier.urihttp://hdl.handle.net/10019.1/100003
dc.language.isoen_ZAen_ZA
dc.publisherHindawien_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectNontuberculous mycobacteriaen_ZA
dc.subjectMiners -- South Africaen_ZA
dc.subjectSputum -- Microbiology -- South Africaen_ZA
dc.subjectSputum -- Examination -- South Africaen_ZA
dc.titleClinical relevance of nontuberculous mycobacteria isolated from sputum in a gold mining workforce in South Africa : an observational, clinical studyen_ZA
dc.typeArticleen_ZA
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