Infective endocarditis - The effect of liposomes as carrier substance for α1-antitrypsin and amicillin

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dc.contributor.authorSchaaf, H. Simonen_ZA
dc.contributor.authorBates, W. D.en_ZA
dc.contributor.authorHanekom, C.en_ZA
dc.contributor.authorNeiteler, B. F.en_ZA
dc.contributor.authorKriegler, A. B.en_ZA
dc.contributor.authorVan der Merwe, P.-L.en_ZA
dc.date.accessioned2011-03-18T14:57:18Z
dc.date.available2011-03-18T14:57:18Z
dc.date.issued1991
dc.descriptionCITATION: Schaaf, H. S. et al. 1991. Infective endocarditis - The effect of liposomes as carrier substance for α1-antitrypsin and amicillin. South African Medical Journal, 79:588-590.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractInfective endocarditis has a high mortality and morbidity rate despite all available treatment. Little attention has been paid to the possible role of polymorphonuclear leucocytes in damage to the heart valves. It was postulated that if the elastases set free from these leucocytes could be neutralised, this would prevent damage to the heart valves. Alpha1-antitrypsin (α1-AT) in liposomes was used to neutralise elastases. This process on its own and in various combinations with ampicillin were compared in animal models. Evaluation was performed by measuring vegetation size, by blood and vegetation cultures, and by light microscopy of the damaged tissue. A statistically significant difference (t-test; P < 0,005, with Bonferroni's correction for multiple comparisons) was found in vegetation size in the groups receiving ampicillin in liposomes, but the hypothesis that α1-AT might reduce valvular damage was not proven.
dc.description.versionPublisher’s version
dc.format.extent3 pages
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7324
dc.language.isoen
dc.publisherHealth & Medical Publishing Group
dc.rights.holderSouth African Medical Journal
dc.subjectInfective endocarditisen_ZA
dc.titleInfective endocarditis - The effect of liposomes as carrier substance for α1-antitrypsin and amicillinen_ZA
dc.typeArticle
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