A multi-parameter approach for predicting prostate cancer
Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Cogent OA
Abstract
Urokinase plasminogen activator (uPA) and its inhibitor (PAI-1) have shown to be of merit as biomarkers for a variety of cancers. The objective of this project was to assay for uPA and PAI-1 in prostate needle biopsy tissue from 217 patients using the FEMTELLE enzyme linked immunosorbent (ELISA) assay, and to
examine the robustness of PAI-1 as a candidate marker in benign prostatic hyperplasia (BPH) and prostate cancer (PCa), as previously identified in a different cohort of 111 patients. These results validate the assertion that PAI-1 levels of >4.5 ng mg−1 protein in prostate biopsies are indicative of prostate malignancy in elderly men, but
further show that tissue from BPH patients in the 70–80 year age interval express significantly high levels of this marker. To address this anomaly, a malignancy index, derived from the concentrations of prostate-specific antigen (PSA), uPA, and PAI-1, and patient age is proposed. This simple index discriminates prostate tissue from BPH and PCa patients with concordance indices of 0.59 and 0.69 when tissues are taken as biopsy or transurethral resection of the prostate (TURP), respectively.
Corresponding indices for PSA as a predictor of prostate disease were 0.67 and 0.73.
Further evaluation of the proposed malignancy index using specimens, such as venous blood, could prove valuable in the search for non-invasive predictive assays.
Description
CITATION: Serafin, A., et al. 2017. A multi-parameter approach for predicting prostate cancer. Cogent Medicine, 4:1329257, doi:10.1080/2331205X.2017.1329257.
The original publication is available at https://www.cogentoa.com
The original publication is available at https://www.cogentoa.com
Keywords
Prostate -- Cancer -- Diagnosis
Citation
Serafin, A., et al. 2017. A multi-parameter approach for predicting prostate cancer. Cogent Medicine, 4:1329257, doi:10.1080/2331205X.2017.1329257