Tuberculosis cross-species transmission in Tanzania : towards a One-Health concept

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dc.contributor.authorMbugi, Erasto V.en_ZA
dc.contributor.authorKatale, Bugwesa Z.en_ZA
dc.contributor.authorKendal, Sharonen_ZA
dc.contributor.authorGood, Liamen_ZA
dc.contributor.authorKibiki, Gibson S.en_ZA
dc.contributor.authorKeyyu, Julius D.en_ZA
dc.contributor.authorGodfrey-Faussett, Peteren_ZA
dc.contributor.authorVan Helden, Paul D.en_ZA
dc.contributor.authorMatee, Mecky I.en_ZA
dc.date.accessioned2013-07-03T08:19:11Z
dc.date.available2013-07-03T08:19:11Z
dc.date.issued2012-07-02
dc.descriptionCITATION: Mbugi, E. V. et al. 2012. Tuberculosis cross-species transmission in Tanzania : towards a One-Health concept. Onderstepoort Journal of Veterinary Research, 79(2), Art. #501, doi:10.4102/ojvr.v79i2.501.en_ZA
dc.descriptionThe original publication is available at http://www.ojvr.org
dc.description.abstractFor centuries, tuberculosis, which is a chronic infection caused by the bacillus Mycobacterium tuberculosis has remained a global health problem. The global burden of tuberculosis has increased, particularly in the Southern African region, mainly due to HIV, and inadequate health systems which has in turn given rise to emergent drug resistant tuberculosis (TB) strains. Bovine tuberculosis (BTB) has also emerged as a significant disease with the tendency for inter-species spread. The extent of interspecies BTB transmission both in urban and rural communities has not been adequately assessed. The phenomenon is of particular importance in rural communities where people share habitats with livestock and wildlife (particularly in areas near national parks and game reserves). Aerosol and oral intake are the major routes of transmission from diseased to healthy individuals, with health care workers often contracting infection nosocomially. Although TB control has increasingly been achieved in high-income countries, the disease, like other poverty-related infections, has continued to be a disaster in countries with low income economies. Transmission of infections occurs not only amongst humans but also between animals and humans (and occasionally vice versa) necessitating assessment of the extent of transmission at their interface. This review explores tuberculosis as a disease of humans which can cross-transmit between humans, livestock and wildlife. The review also addresses issues underlying the use of molecular biology, genetic sequencing and bioinformatics as t tools to understand the extent of inter-species cross-transmission of TB in a ‘One Health’ context.en_ZA
dc.description.urihttp://www.ojvr.org/index.php/ojvr/article/view/501
dc.description.versionPublisher's version
dc.format.extent6 pages
dc.identifier.citationMbugi, E. V. et al. 2012. Tuberculosis cross-species transmission in Tanzania : towards a One-Health concept. Onderstepoort Journal of Veterinary Research, 79(2), Art. #501, doi:10.4102/ojvr.v79i2.501.
dc.identifier.issn2219-0635 (online)
dc.identifier.issn0030-2465 (print)
dc.identifier.otherdoi:10.4102/ojvr.v79i2.501
dc.identifier.urihttp://hdl.handle.net/10019.1/81876
dc.language.isoen_ZAen_ZA
dc.publisherAOSIS Publishing
dc.rights.holderAuthors retain copyright
dc.subjectTuberculosis in cattleen_ZA
dc.subjectTuberculoses -- Molecular aspectsen_ZA
dc.subjectTuberculosis -- Transmission -- Tanzaniaen_ZA
dc.subjectZoonosesen_ZA
dc.subjectAnimals as carriers of diseaseen_ZA
dc.titleTuberculosis cross-species transmission in Tanzania : towards a One-Health concepten_ZA
dc.typeArticle
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