Investigation of household contacts of pulmonary tuberculosis patients increases case detection in Mwanza City, Tanzania

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dc.contributor.authorBeyanga, Medarden_ZA
dc.contributor.authorKidenya, Benson R.en_ZA
dc.contributor.authorGerwing-Adima, Lisaen_ZA
dc.contributor.authorOchodo, Eleanoren_ZA
dc.contributor.authorMshana, Stephen E.en_ZA
dc.contributor.authorKasang, Christaen_ZA
dc.date.accessioned2019-10-21T11:53:29Z
dc.date.available2019-10-21T11:53:29Z
dc.date.issued2018-03
dc.descriptionCITATION: Beyanga, M. et al. 2018. Investigation of household contacts of pulmonary tuberculosis patients increases case detection in Mwanza City, Tanzania. BMC Infectious Diseases, 18:110, doi.org/10.1186/s12879-018-3036-6.en_ZA
dc.descriptionThe original publication is available at https://bmcinfectdis.biomedcentral.comen_ZA
dc.description.abstractBackground: Tuberculosis (TB) contact tracing is a key strategy for containing TB and provides addition to the passive case finding approach. However, this practice has not been implemented in Tanzania, where there is unacceptably high treatment gap of 62.1% between cases estimated and cases detected. Therefore calls for more aggressive case finding for TB to close this gap. We aimed to determine the magnitude and predictors of bacteriologically-confirmed pulmonary TB among household contacts of bacteriologically-confirmed pulmonary TB index cases in the city of Mwanza, Tanzania. Methods: This study was carried out from August to December 2016 in Mwanza city at the TB outpatient clinics of Tertiary Hospital of the Bugando Medical Centre, Sekou-Toure Regional Hospital, and Nyamagana District Hospital. Bacteriologically-confirmed TB index cases diagnosed between May and July 2016 were identified from the laboratory registers book. Contacts were traced by home visits by study TB nurses, and data were collected using a standardized TB screening questionnaire. To detect the bacterioriologically-confirmed pulmonary TB, two sputum samples per household contact were collected under supervision for all household contacts following standard operating procedures. Samples were transported to the Bugando Medical Centre TB laboratory for investigation for TB using fluorescent smear microscopy, GeneXpert MTB/RIF and Löwenstein–Jensen (LJ) culture. Logistic regression was used to determine predictors of bacteriologically-confirmed pulmonary TB among household contacts. Results: During the study period, 456 household contacts from 93 TB index cases were identified. Among these 456 household contacts, 13 (2.9%) were GeneXpert MTB/RIF positive, 18 (3.9%) were MTB-culture positive and four (0.9%) were AFB-smear positive. Overall, 29 (6.4%) of contacts had bacteriologically-confirmed pulmonary TB. Predictors of bacteriologically-confirmed pulmonary TB among household contacts were7being married (Odds ratio [OR], 3.3; 95% confidence interval [CI], 1.4–8.0; p = 0.012) and consuming less than three meals a day (OR, 3.7; 95% CI, 1.6–8.7; p = 0.009). Conclusions: Our data suggest that in Mwanza, Tanzania, seven in 100 contacts living in the same house with a TB patient develop bacteriologically-confirmed pulmonary TB. These results therefore underscore the need to implement routine TB contact tracing to control tuberculosis in high TB burden countries such as Tanzania.en_ZA
dc.description.sponsorshipMedical Mission Institute, Wuerzburg, Germanyen_ZA
dc.description.versionPublishers versionen_ZA
dc.identifier.citationBeyanga, M. et al. 2018. Investigation of household contacts of pulmonary tuberculosis patients increases case detection in Mwanza City, Tanzania. BMC Infectious Diseases, 18:110, doi.org/10.1186/s12879-018-3036-6.en_ZA
dc.identifier.issn1471-2334 (online)
dc.identifier.otherdoi.org/10.1186/s12879-018-3036-6
dc.identifier.urihttp://hdl.handle.net/10019.1/106677
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Centralen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectTuberculosisen_ZA
dc.subjectBacteriologically-confirmed pulmonary tuberculosisen_ZA
dc.subjectMwanzaen_ZA
dc.subjectTanzaniaen_ZA
dc.subjectTBen_ZA
dc.subjectContaining TBen_ZA
dc.subjectMycobacterium tuberculosisen_ZA
dc.titleInvestigation of household contacts of pulmonary tuberculosis patients increases case detection in Mwanza City, Tanzaniaen_ZA
dc.typeArticleen_ZA
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