Lymphocyte measures in treatment-naïve 13-15-year old adolescents with alcohol use disorders

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dc.contributor.authorNaude C.E.
dc.contributor.authorBouic P.
dc.contributor.authorSenekal M.
dc.contributor.authorKidd M.
dc.contributor.authorFerrett H.L.
dc.contributor.authorFein G.
dc.contributor.authorCarey P.D.
dc.date.accessioned2011-10-13T16:59:01Z
dc.date.available2011-10-13T16:59:01Z
dc.date.issued2011
dc.description.abstractMany adolescents have chronic exposure to hazardous levels of alcohol. This is likely to be a significant predictor of health outcomes, including those related to immunity. We assessed substance use and biochemical immunological parameters in heavy drinking adolescents (meeting DSM-IV criteria for alcohol dependence) and light/nondrinking control adolescents in Cape Town. Lifetime alcohol dose, measured in standard units of alcohol, was orders of magnitude higher in alcohol-dependent (AD) participants than controls. All adolescent AD had a "weekends-only" style of alcohol consumption. The AD group was chosen to represent relatively "pure" AD, with minimal other drug use and no psychiatric diagnoses. With these narrow parameters in place, we found that AD adolescents were lymphopenic compared with controls, with significantly lower mean numbers of absolute circulating CD3+, CD4+, and CD8+ T-lymphocytes. On conclusion, we found that adolescent AD individuals with excessive alcohol intake, in a weekend binge-drinking style but without comorbid drug or psychiatric disorders, may be at increased risk of lymphopenia. This alcohol misuse may increase infectious disease susceptibility (including TB and HIV) by reducing immune system capabilities. Complex interactions of alcohol with other documented high-risk activities may further compound health risks. © 2011 Elsevier Ltd.
dc.description.versionArticle
dc.identifier.citationAlcohol
dc.identifier.citation45
dc.identifier.citation5
dc.identifier.citationhttp://www.scopus.com/inward/record.url?eid=2-s2.0-79959538220&partnerID=40&md5=31ac966623ffcdc2f49b566e12061ff5
dc.identifier.issn7418329
dc.identifier.other10.1016/j.alcohol.2011.02.307
dc.identifier.urihttp://hdl.handle.net/10019.1/16950
dc.subjectAdolescents
dc.subjectAlcohol
dc.subjectAlcohol use disorders
dc.subjectImmunity
dc.subjectLymphocytes
dc.subjectSouth africa
dc.subjectadolescent
dc.subjectalcohol consumption
dc.subjectalcoholism
dc.subjectarticle
dc.subjectbinge drinking
dc.subjectCD3+ T lymphocyte
dc.subjectCD4 CD8 ratio
dc.subjectCD4+ T lymphocyte
dc.subjectCD8+ T lymphocyte
dc.subjectclinical article
dc.subjectcomorbidity
dc.subjectcontrolled study
dc.subjectdiagnostic and statistical manual of mental disorders
dc.subjectdisease association
dc.subjectdisease predisposition
dc.subjectdrinking behavior
dc.subjectfemale
dc.subjecthealth hazard
dc.subjecthigh risk population
dc.subjecthuman
dc.subjecthuman cell
dc.subjectHuman immunodeficiency virus infection
dc.subjectimmune deficiency
dc.subjectimmunological parameters
dc.subjectlymphocyte count
dc.subjectlymphocytopenia
dc.subjectmale
dc.subjectnatural killer cell
dc.subjectregulatory T lymphocyte
dc.subjectSouth Africa
dc.subjecttuberculosis
dc.titleLymphocyte measures in treatment-naïve 13-15-year old adolescents with alcohol use disorders
dc.typeArticle
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