Association between clinical and environmental factors and the gut microbiota profiles in young South African children

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dc.contributor.authorNel Van Zyl, Kristienen_ZA
dc.contributor.authorWhitelaw, Andrew C.en_ZA
dc.contributor.authorHesseling, Anneke C.en_ZA
dc.contributor.authorSeddon, James A.en_ZA
dc.contributor.authorDemers, Anne‑Marieen_ZA
dc.contributor.authorNewton‑Foot, Maeen_ZA
dc.date.accessioned2021-12-10T07:17:54Z
dc.date.available2021-12-10T07:17:54Z
dc.date.issued2021
dc.descriptionCITATION: Nel Van Zyl, K., et al. 2021. Association between clinical and environmental factors and the gut microbiota profiles in young South African children. Scientific Reports, 11:15895, doi:1038/s41598-021-95409-5.en_ZA
dc.descriptionThe original publication is available at https://www.nature.comen_ZA
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Funden_ZA
dc.description.abstractENGLISH ABSTRACT: Differences in the microbiota in populations over age and geographical locations complicate cross-study comparisons, and it is therefore essential to describe the baseline or control microbiota in each population. This includes the determination of the influence of demographic, clinical and environmental factors on the microbiota in a setting, and elucidates possible bias introduced by these factors, prior to further investigations. Little is known about the microbiota of children in South Africa after infancy. We provide a detailed description of the gut microbiota profiles of children from urban Cape Town and describe the influences of various clinical and environmental factors in different age groups during the first 5 years of life. Prevotella was the most common genus identified in the participants, and after infancy, the gut bacteria were dominated by Firmicutes and Bacteroidetes. In this setting, children exposed to antibiotics and indoor cooking fires were at the most risk for dysbiosis, showing significant losses in gut bacterial diversity.en_ZA
dc.description.urihttps://www.nature.com/articles/s41598-021-95409-5
dc.description.versionPublisher's version
dc.format.extent13 pagesen_ZA
dc.identifier.citationVan Zyl, K. N., et al. 2021. Association between clinical and environmental factors and the gut microbiota profiles in young South African children. Scientific Reports, 11:15895, doi:1038/s41598-021-95409-5en_ZA
dc.identifier.issn2045-2322 (online)
dc.identifier.otherdoi:1038/s41598-021-95409-5
dc.identifier.urihttp://hdl.handle.net/10019.1/123550
dc.language.isoen_ZAen_ZA
dc.publisherNature Research (part of Springer Nature)en_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectMicrobiotaen_ZA
dc.subjectBacterial diversityen_ZA
dc.subjectInflammatory bowel diseasesen_ZA
dc.subjectMicroorganisms -- Identificationen_ZA
dc.subjectBacteriology, Clinicalen_ZA
dc.subjectHealth -- Environmental aspectsen_ZA
dc.titleAssociation between clinical and environmental factors and the gut microbiota profiles in young South African childrenen_ZA
dc.typeArticleen_ZA
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