11β-Hydroxyandrostenedione returns to the steroid arena : biosynthesis, metabolism and function

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dc.contributor.authorBloem, Liezl M.
dc.contributor.authorStorbeck, Karl-Heinz
dc.contributor.authorSchloms, Lindie
dc.contributor.authorSwart, Amanda C.
dc.date.accessioned2014-01-31T08:02:29Z
dc.date.available2014-01-31T08:02:29Z
dc.date.issued2013-10
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.en_ZA
dc.descriptionThe original publication is available at http://www.mdpi.com/journal/moleculesen_ZA
dc.description.abstractThe biological significance of 11β-hydroxyandrostenedione (11OHA4) has eluded researchers for the past six decades. It is now known that 11OHA4 is biosynthesized in the androgen arm of the adrenal steroidogenesis pathway and subsequently metabolized by steroidogenic enzymes in vitro, serving as precursor to recognized and novel androgenic steroids. These in vitro findings extend beyond the adrenal, suggesting that 11OHA4 could be metabolized in steroid-responsive peripheral tissues, as is the case for androgen precursor metabolites of adrenal origin. The significance thereof becomes apparent when considering that the metabolism of 11OHA4 in LNCaP androgen dependent prostate cancer cells yields androgenic steroid metabolites. It is thus possible that 11OHA4 may be metabolized to yield ligands for steroid receptors in not only the prostate but also in other steroid-responsive tissues. Future investigations of 11OHA4 may therefore characterize it as a vital steroid with far-reaching physiological consequences. An overview of the research on 11OHA4 since its identification in 1953 will be presented, with specific focus on the most recent works that have advanced our understanding of its biological role, thereby underscoring its relevance in health and disease.en_ZA
dc.description.sponsorshipStellenbosch Universityen_ZA
dc.description.versionPublishers' versionen_ZA
dc.format.extent17 p.
dc.identifier.citationBloem, L. M., Storbeck, K. H., Schloms, L. & Swart, A. C. 2013. 11β-Hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function. Molecules, 18:13228-13244, doi:10.3390/molecules181113228.en_ZA
dc.identifier.issn1420-3049 (print)
dc.identifier.issn1420-3049 (online)
dc.identifier.otherdoi:10.3390/molecules181113228
dc.identifier.urihttp://hdl.handle.net/10019.1/86102
dc.language.isoen_ZAen_ZA
dc.publisherMDPIen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectAdrenal H295Ren_ZA
dc.subjectAndrosteroneen_ZA
dc.subjectCastration resistant prostate cancer (CRPC)en_ZA
dc.subjectCytochrome P450en_ZA
dc.subjectHydroxysteroid dehydrogenase (HSD)en_ZA
dc.subjectSteroid 5α-reductaseen_ZA
dc.title11β-Hydroxyandrostenedione returns to the steroid arena : biosynthesis, metabolism and functionen_ZA
dc.typeArticleen_ZA
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