Effect of binding immunoglobulin protein on induction of regulatory B cells with killer phenotype during inflammation and disease

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dc.contributor.authorMotaung, Bonganien_ZA
dc.contributor.authorLoxton, Andre G.en_ZA
dc.date.accessioned2021-07-06T13:18:46Z
dc.date.available2021-07-06T13:18:46Z
dc.date.issued2019-03-05
dc.descriptionCITATION: Motaung, B. & Loxton, A. G. 2019. Effect of binding immunoglobulin protein on induction of regulatory B cells with killer phenotype during inflammation and disease. Future Science OA, 5(3):FSO379, doi:10.4155/fsoa-2018-0121.en_ZA
dc.descriptionThe original publication is available at https://www.future-science.comen_ZA
dc.description.abstractImmune responses result from different immune cells acting in synergy to successfully fight infections. This requires a high degree of regulation to prevent excessive production of inflammatory products leading to other disease forms. Regulatory B cells are classified based on surface immunoglobulin expression. These cells are reported to resolve inflammation during chronic or autoimmune diseases. However, during chronic inflammation, their frequencies have been shown to be affected, and they can be induced by exposure to extracellular binding immunoglobulin protein (BiP). This review focuses on the effects on immune cells by extracellular or secreted BiP during various chronic inflammatory responses. For example, cell stress associated with Mycobacterium tuberculosis infection leads to accumulation of unfolded proteins that subsequently activate BiP and its three signal transducers intracellularly. Furthermore, BiP can be translocated from the endoplasmic reticulum to the extracellular environment where it binds immune cells as an autoantigen and leads to functional changes.en_ZA
dc.description.urihttps://www.future-science.com/doi/full/10.4155/fsoa-2018-0121
dc.description.versionPublisher's version
dc.format.extent12 pages : illustrationsen_ZA
dc.identifier.citationMotaung, B. & Loxton, A. G. 2019. Effect of binding immunoglobulin protein on induction of regulatory B cells with killer phenotype during inflammation and disease. Future Science OA, 5(3):FSO379, doi:10.4155/fsoa-2018-0121.
dc.identifier.issn2056-5623 (online)
dc.identifier.otherdoi:10.4155/fsoa-2018-0121
dc.identifier.urihttp://hdl.handle.net/10019.1/110648
dc.language.isoen_ZAen_ZA
dc.publisherFuture Science
dc.rights.holderAuthors retain copyright
dc.subjectApoptosisen_ZA
dc.subjectAutoimmune diseasesen_ZA
dc.subjectImmunoglobulin-binding proteins -- Bacterialen_ZA
dc.subjectChronic diseasesen_ZA
dc.subjectImmune responseen_ZA
dc.subjectMycobacterium tuberculosis -- Infectionsen_ZA
dc.subjectNecrosisen_ZA
dc.subjectInflammationen_ZA
dc.subjectB cellsen_ZA
dc.subjectB Lymphocytesen_ZA
dc.titleEffect of binding immunoglobulin protein on induction of regulatory B cells with killer phenotype during inflammation and diseaseen_ZA
dc.typeArticleen_ZA
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