Linking LOXL2 to Cardiac Interstitial Fibrosis

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dc.contributor.authorErasmus, Melisseen_ZA
dc.contributor.authorSamodien, Ebrahimen_ZA
dc.contributor.authorLecour, Sandrineen_ZA
dc.contributor.authorCour, Martinen_ZA
dc.contributor.authorLorenzo, Oscaren_ZA
dc.contributor.authorDludla, Phiwayinkosien_ZA
dc.contributor.authorPheiffer, Carmenen_ZA
dc.contributor.authorJohnson, Rabiaen_ZA
dc.date.accessioned2022-09-20T12:35:52Zen_ZA
dc.date.available2022-09-20T12:35:52Zen_ZA
dc.date.issued2020-08en_ZA
dc.descriptionCITATION: Erasmus M. et al. 2020. Linking LOXL2 to Cardiac Interstitial Fibrosis. International Journal of Molecular Sciences, 21(16). doi:10.3390/ijms21165913en_ZA
dc.descriptionThe original publication is available at https://www.mdpi.com/journal/ijmsen_ZA
dc.description.abstractCardiovascular diseases (CVDs) are the leading causes of death worldwide. CVD pathophysiology is often characterized by increased stiffening of the heart muscle due to fibrosis, thus resulting in diminished cardiac function. Fibrosis can be caused by increased oxidative stress and inflammation, which is strongly linked to lifestyle and environmental factors such as diet, smoking, hyperglycemia, and hypertension. These factors can affect gene expression through epigenetic modifications. Lysyl oxidase like 2 (LOXL2) is responsible for collagen and elastin cross-linking in the heart, and its dysregulation has been pathologically associated with increased fibrosis. Additionally, studies have shown that, LOXL2 expression can be regulated by DNA methylation and histone modification. However, there is a paucity of data on LOXL2 regulation and its role in CVD. As such, this review aims to gain insight into the mechanisms by which LOXL2 is regulated in physiological conditions, as well as determine the downstream effectors responsible for CVD development.en_ZA
dc.description.urihttps://www.mdpi.com/1422-0067/21/16/5913en_ZA
dc.description.versionPublishers versionen_ZA
dc.format.extent18 pagesen_ZA
dc.identifier.citationErasmus M. et al. 2020. Linking LOXL2 to Cardiac Interstitial Fibrosis. International Journal of Molecular Sciences, 21(16). doi:10.3390/ijms21165913en_ZA
dc.identifier.issn1422-0067 (online)en_ZA
dc.identifier.issn1661-6596 (print)en_ZA
dc.identifier.otherdoi:10.3390/ijms21165913en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/125740en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherMDPIen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectHeart -- Fibrosisen_ZA
dc.subjectEpigeneticsen_ZA
dc.subjectLysyl oxidaseen_ZA
dc.subjectMethylationen_ZA
dc.subjectCardiovascular system -- Diseasesen_ZA
dc.titleLinking LOXL2 to Cardiac Interstitial Fibrosisen_ZA
dc.typeArticleen_ZA
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