A comparison of the effects of citalopram and moclobemide on resting brain perfusion in social anxiety disorder.

Simple item page
dc.contributor.authorWarwick, James M.en_ZA
dc.contributor.authorCarey P.
dc.contributor.authorVan der Linden G.
dc.contributor.authorPrinsloo C.
dc.contributor.authorNiehaus D.
dc.contributor.authorSeedat S.
dc.contributor.authorDupont P.
dc.contributor.authorStein D.J.
dc.date.accessioned2011-05-15T15:59:59Z
dc.date.available2011-05-15T15:59:59Z
dc.date.issued2006
dc.description.abstractINTRODUCTION: The serotonin specific reuptake inhibitor (SSRI) citalopram and the reversible mono-amine oxidase-A inhibitor (RIMA) moclobemide have both been used successfully for the treatment of social anxiety disorder (SAD). In this study we investigate the effects of these compounds on resting brain function using single photon emission computed tomography (SPECT). METHODS: Subjects meeting DSM-IV criteria for SAD underwent regional cerebral blood flow (rCBF) SPECT using Tc-HMPAO at baseline and after 8 weeks of treatment with either citalopram or moclobemide. Using statistical parametric mapping brain SPECT studies were analysed to determine the effects of treatment on rCBF, to compare the effects of citalopram and moclobemide, and to detect correlations between changes in rCBF and clinical response. RESULTS: Subjects received citalopram (n=17) or moclobemide (n=14) as therapy. Subjects in both treatment groups demonstrated a significant improvement of SAD symptoms as measured by the Liebowitz Social Anxiety Scale total score. All subjects demonstrated a decrease in rCBF in the insulae post therapy. Subjects receiving citalopram had decreased superior cingulate rCBF after therapy compared to those receiving moclobemide. CONCLUSION: Both SSRI's and RIMA's decreased rCBF in the insulae during treatment of SAD; an effect that may be consistent with the role of these regions in processing internal somatic cues evoked by emotional stimuli. Citalopram had a greater effect on superior cingulate perfusion, an effect that is consistent with evidence of high levels of 5-HT transporters in this region.
dc.description.versionArticle
dc.identifier.citationMetabolic brain disease
dc.identifier.citation21
dc.identifier.citation03-Feb
dc.identifier.issn8857490
dc.identifier.urihttp://hdl.handle.net/10019.1/11463
dc.subjectantidepressant agent
dc.subjectcitalopram
dc.subjectmoclobemide
dc.subjectserotonin uptake inhibitor
dc.subjectadult
dc.subjectagoraphobia
dc.subjectarticle
dc.subjectbrain
dc.subjectbrain circulation
dc.subjectcomparative study
dc.subjectdepth perception
dc.subjectdrug effect
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectpsychological rating scale
dc.subjectscintiscanning
dc.subjectsingle photon emission computer tomography
dc.subjectAdult
dc.subjectAgoraphobia
dc.subjectAntidepressive Agents
dc.subjectBrain
dc.subjectCerebrovascular Circulation
dc.subjectCitalopram
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMoclobemide
dc.subjectPsychiatric Status Rating Scales
dc.subjectSerotonin Uptake Inhibitors
dc.subjectSpace Perception
dc.subjectTomography, Emission-Computed, Single-Photon
dc.subjectSocial phobia -- Treatmenten_ZA
dc.subjectPerfusion (Physiology)en_ZA
dc.subjectBrain -- Effect of drugs onen_ZA
dc.subjectBrain -- Localization of functionsen_ZA
dc.subjectSingle-photon emission computed tomographyen_ZA
dc.subjectCerebral circulation -- Testingen_ZA
dc.titleA comparison of the effects of citalopram and moclobemide on resting brain perfusion in social anxiety disorder.
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Publications