Oral midazolam in paediatric premedication

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dc.contributor.authorPayne, K. A.en_ZA
dc.contributor.authorCoetzee, A. R.en_ZA
dc.contributor.authorMattheyse, F. J.en_ZA
dc.contributor.authorDawes, T.en_ZA
dc.date.accessioned2011-03-18T14:59:34Z
dc.date.available2011-03-18T14:59:34Z
dc.date.issued1991
dc.descriptionCITATION: Payne, K. A., et al. 1991. Oral midazolam in paediatric premedication. South African Medical Journal, 79:372-375.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractIn a premedication study involving 135 children, aged 1-10 years, four regimens were investigated: (i) no premedication; (ii) oral trimeprazine tartrate 2 mg/kg, methadone 0.1 mg/kg, droperidol 0.15 mg/kg (TMD); (iii) intramuscular midazolam (Dormicum; Roche) 0.15 mg/kg; and (iv) oral midazolam 0.45 mg/kg. All premedications were given 60 minutes before a standard halothane anaesthetic. No impairment of cardiovascular stability occurred but after premedication the mean oxygen saturation decreased by 1.6% and 1.1%, respectively, in the intramuscular midazolam and TMD groups. Overall, children under 5 years of age behaved less satisfactorily in the holding room and at induction, than those over 5 years (P<0.01). Midazolam, intramuscularly and orally, produced more satisfactory behaviour than the other two regimens (P<0.05) and, combined with a 70% more rapid recovery than the TMD regimen (P<0.05), suggests that oral midazolam is a more effective paediatric premedication agent than placebo or TMD.
dc.description.urihttp://archive.samj.org.za/1991%20VOL%2079%20Jan-Jun/Articles/04%20April/1.5%20ORAL%20MIDAZOLAM%20IN%20PAEDIATRIC%20PREMEDICATION.%20K.A.%20Payne,%20A.R.%20Coetzee,%20F.J.%20Mattheyse%20and%20T.%20D.pdf
dc.description.versionPublisher’s version
dc.identifier.citationPayne, K. A., et al. 1991. Oral midazolam in paediatric premedication. South African Medical Journal, 79:372-375
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7913
dc.language.isoenen_ZA
dc.publisherHealth & Medical Publishing Group
dc.rights.holderSouth African Medical Journal
dc.subjectMidazolam
dc.subjectAnesthetics
dc.titleOral midazolam in paediatric premedicationen_ZA
dc.typeArticle
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