Cross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertension

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dc.contributor.authorMasilela, Charityen_ZA
dc.contributor.authorPearce, Brendonen_ZA
dc.contributor.authorOngole, Joven Jebioen_ZA
dc.contributor.authorAdeniyi, Oladele Vincenten_ZA
dc.contributor.authorJohnson, Rabiaen_ZA
dc.contributor.authorBenjeddou, Mongien_ZA
dc.date.accessioned2023-05-18T11:59:13Zen_ZA
dc.date.available2023-05-18T11:59:13Zen_ZA
dc.date.issued2021en_ZA
dc.descriptionCITATION: Masilela, C. et al. 2021. Cross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertension. Medicine, 100(46):e27836, doi:10.1097/MD.0000000000027836.en_ZA
dc.descriptionThe original publication is available at https://journals.lww.comen_ZA
dc.description.abstractThis study investigates the association of 5 single nucleotide polymorphisms (SNPs) in selected genes (ABO, VEGFA, BDKRB2, NOS3, and ADRB2) with blood pressure (BP) response to enalapril. The study further assessed genetic interactions that exist within these genes and their implications in enalapril treatment response among South African adults with hypertension. A total of 284 participants belonging to the Nguni tribe of South Africa on continuous treatment for hypertension were recruited. Five SNPs in enalapril pharmacogenes were selected and genotyped using MassArray. Uncontrolled hypertension was defined as BP ≥140/90 mm Hg. The association between genotypes, alleles, and BP response to treatment was determined by fitting multivariate logistic regression model analysis, and genetic interactions between SNPs were assessed by multifactor dimensionality reduction. Majority of the study participants were female (75.00%), Xhosa (78.87%), and had uncontrolled hypertension (69.37%). All 5 SNPs were exclusively detected among Swati and Zulu participants. In the multivariate (adjusted) logistic model analysis, ADRB2 rs1042714 GC (adjusted odds ratio [AOR] = 2.31; 95% confidence interval [CI] 1.02–5.23; P = .044) and BDKRB2 rs1799722 CT (AOR = 2.74; 95% CI 1.19–6.28; P = .017) were independently associated with controlled hypertension in response to enalapril. While the C allele of VEGFA rs699947 (AOR = 0.37; 95% CI 0.15–0.94; P = .037) was significantly associated with uncontrolled hypertension. A significant interaction between rs699947, rs495828, and rs2070744 (cross-validation consistency = 10/10; P = .0005) in response to enalapril was observed. We confirmed the association of rs1042714 (ADRB2) and rs1799722 (BDKRB2) with controlled hypertension and established an interaction between rs699947 (VEGFA), rs495828 (ABO), and rs2070744 (NOS3) with BP response to enalapril. Our findings have provided substantial evidence for the use of SNPs as predictors for enalapril response among South Africans adults with hypertension.en_ZA
dc.description.sponsorshipSouth African Medical Research Councilen_ZA
dc.description.versionPublisher's versionen_ZA
dc.format.extent8 pagesen_ZA
dc.identifier.citationMasilela, C. et al. 2021. Cross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertension. Medicine, 100(46):e27836, doi:10.1097/MD.0000000000027836.en_ZA
dc.identifier.issn1536-5964 (online)en_ZA
dc.identifier.otherdoi:10.1097/MD.0000000000027836en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/127423en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherWolters Kluwer Healthen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subject.lcshSingle nucleotide polymorphismsen_ZA
dc.subject.lcshBlood pressure -- Treatmenten_ZA
dc.subject.lcshHypertension -- Alternative treatmenten_ZA
dc.titleCross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertensionen_ZA
dc.typeArticleen_ZA
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