Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community

Simple item page
dc.contributor.authorKatoto, Patrick D. M. C.en_ZA
dc.contributor.authorKayembe‑Kitenge, Tonyen_ZA
dc.contributor.authorPollitt, Krystal J. Godrien_ZA
dc.contributor.authorMartens, Dries S.en_ZA
dc.contributor.authorGhosh, Manosijen_ZA
dc.contributor.authorNachega, Jean B.en_ZA
dc.contributor.authorNemery, Benoiten_ZA
dc.contributor.authorNawrot, Tim S.en_ZA
dc.date.accessioned2023-04-03T10:24:56Zen_ZA
dc.date.available2023-04-03T10:24:56Zen_ZA
dc.date.issued2021-02en_ZA
dc.descriptionCITATION: Katoto, P. D. M. C. et al. 2021. Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community. Scientific Reports, 11:4031, doi:10.1038/s41598-021-83281-2.en_ZA
dc.descriptionThe original publication is available at https://www.nature.comen_ZA
dc.description.abstractTelomere length (TL) is a marker of ageing and mitochondrial DNA (mtDNA) is an early marker of inflammation caused by oxidative stress. We determined TL and mtDNA content among active pulmonary tuberculosis (PTB) patients to assess if these cellular biomarkers differed between artisanal miners and non-miners, and to assess if they were predictive of treatment outcome. We conducted a prospective cohort study from August 2018 to May 2019 involving newly diagnosed PTB patients at three outpatient TB clinics in a rural Democratic Republic of Congo. We measured relative TL and mtDNA content in peripheral blood leukocytes (at inclusion) via qPCR and assessed their association with PTB treatment outcome. We included 129 patients (85 miners and 44 non-miners) with PTB (median age 40 years; range 5–71 years, 22% HIV-coinfected). For each increase in year and HIV-coinfection, TL shortened by − 0.85% (− 0.19 to − 0.52) (p ≤ 0.0001) and − 14% (− 28.22 to − 1.79) (p = 0.02) respectively. Independent of these covariates, patients with longer TL were more likely to have successful TB treatment [adjusted hazard ratio; 95% CI 1.27 for a doubling of leucocyte telomere length at baseline; 1.05–1.44] than patients with a shorter TL. Blood mtDNA content was not predictive for PTB outcome. For a given chronological age, PTB patients with longer telomeres at time of diagnosis were more likely to have successful PTB treatment outcome.en_ZA
dc.description.urihttps://www.nature.com/articles/s41598-021-83281-2en_ZA
dc.description.versionPublisher's versionen_ZA
dc.format.extent10 pagesen_ZA
dc.identifier.citationKatoto, P. D. M. C. et al. 2021. Telomere length and outcome of treatment for pulmonary tuberculosis in a gold mining community. Scientific Reports, 11:4031, doi:10.1038/s41598-021-83281-2.en_ZA
dc.identifier.issn2045-2322 (online)en_ZA
dc.identifier.otherdoi:10.1038/s41598-021-83281-2en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/126758en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherNatureen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectTuberculosis, Pulmonaryen_ZA
dc.subjectTelomereen_ZA
dc.subjectOxidative stressen_ZA
dc.subjectSmall-scale minersen_ZA
dc.subjectInflammation -- Alternative treatmenten_ZA
dc.subjectLungs -- Diseases -- Treatmenten_ZA
dc.titleTelomere length and outcome of treatment for pulmonary tuberculosis in a gold mining communityen_ZA
dc.typeArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
katoto_telomere_2021.pdf
Size:
863.17 KB
Format:
Adobe Portable Document Format
Description:
Download article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Infectious Diseases)