Erythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology implicated in severe hypercoagulation and vascular complications in COVID-19

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dc.contributor.authorVenter, Chantelleen_ZA
dc.contributor.authorBezuidenhout, Johannes Andriesen_ZA
dc.contributor.authorLaubscher, Gert Jacobusen_ZA
dc.contributor.authorLourens, Petrus Johannesen_ZA
dc.contributor.authorSteenkamp, Janamien_ZA
dc.contributor.authorKell, Douglas B.en_ZA
dc.contributor.authorPretorius, Etheresiaen_ZA
dc.date.accessioned2022-09-19T14:27:32Z
dc.date.available2022-09-19T14:27:32Z
dc.date.issued2020-11-03
dc.descriptionCITATION: Venter, C. et al. 2020. Erythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology Implicated in Severe Hypercoagulation and Vascular Complications in COVID-19. International Journal of Molecular Sciences, 21(21). doi:10.3390/ijms21218234en_ZA
dc.descriptionThe original publication is available at https://www.mdpi.com/journal/ijmsen_ZA
dc.description.abstractProgressive respiratory failure is seen as a major cause of death in severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection. Relatively little is known about the associated morphologic and molecular changes in the circulation of these patients. In particular, platelet and erythrocyte pathology might result in severe vascular issues, and the manifestations may include thrombotic complications. These thrombotic pathologies may be both extrapulmonary and intrapulmonary and may be central to respiratory failure. Previously, we reported the presence of amyloid microclots in the circulation of patients with coronavirus disease 2019 (COVID-19). Here, we investigate the presence of related circulating biomarkers, including C-reactive protein (CRP), serum ferritin, and P-selectin. These biomarkers are well-known to interact with, and cause pathology to, platelets and erythrocytes. We also study the structure of platelets and erythrocytes using fluorescence microscopy (using the markers PAC-1 and CD62PE) and scanning electron microscopy. Thromboelastography and viscometry were also used to study coagulation parameters and plasma viscosity. We conclude that structural pathologies found in platelets and erythrocytes, together with spontaneously formed amyloid microclots, may be central to vascular changes observed during COVID-19 progression, including thrombotic microangiopathy, diffuse intravascular coagulation, and large-vessel thrombosis, as well as ground-glass opacities in the lungs. Consequently, this clinical snapshot of COVID-19 strongly suggests that it is also a true vascular disease and considering it as such should form an essential part of a clinical treatment regime.en_ZA
dc.description.urihttps://www.mdpi.com/1422-0067/21/21/8234
dc.description.versionPublishers versionen_ZA
dc.format.extent14 pages : illustrationsen_ZA
dc.identifier.citationVenter, C. et al. 2020. Erythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology Implicated in Severe Hypercoagulation and Vascular Complications in COVID-19. International Journal of Molecular Sciences, 21(21). doi:10.3390/ijms21218234en_ZA
dc.identifier.issn1422-0067 (online)
dc.identifier.issn1661-6596 (print)
dc.identifier.otherdoi:10.3390/ijms21218234
dc.identifier.urihttp://hdl.handle.net/10019.1/125738
dc.language.isoen_ZAen_ZA
dc.publisherMDPIen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectCOVID-19 (Disease)en_ZA
dc.subjectPlatelet and Erythrocyte pathologyen_ZA
dc.subjectSerum ferritinen_ZA
dc.subjectOxygen saturationen_ZA
dc.subjectProgressive respiratory failureen_ZA
dc.subjectCOVID-19 (Disease) -- Epidemiologyen_ZA
dc.subjectCoronavirus infectionsen_ZA
dc.titleErythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology implicated in severe hypercoagulation and vascular complications in COVID-19en_ZA
dc.typeArticleen_ZA
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