Not all progestins are the same : implications for usage
Date
2004-11
Authors
Hapgood, Janet P.
Koubovec, Dominique
Louw, Ann
Africander, Donita
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Recent clinical evidence showing unexpected side-effects
of progestins used in contraception and hormone replacement
therapy has highlighted the importance of choice of
synthetic progestin. The molecularmechanisms of action
of the relatively nonspecific and most widely used
synthetic progestins, medroxyprogesterone acetate and
norethisterone, are discussed in the context of this
recent clinical evidence. Future directions involving a
more mechanism-based approach for improved therapeutics,
with greater specificity and fewer side-effects,
are discussed.
Description
The original publication is available at www.sciencedirect.com
Keywords
Progestational hormones -- Physiologcial effect, Progesterone -- Physiological effect, Contraceptives, Hormone replacement therapy
Citation
Hapgood, J. P., Koubovec, D. Louw, A. & Africander, D. 2004. Not all progestins are the same: implications for usage. Trends in pharmacological sciences, 25(11), 554-557, doi:10.1016/j.tips.2004.09.005