The beneficial role of Anchomanes difformis in STZ-induced reproductive dysfunction in male Wistar rats

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dc.contributor.authorAlabi, Toyin Dorcasen_ZA
dc.contributor.authorde Villiers, Charonen_ZA
dc.contributor.authordu Plessis, Stephan S.en_ZA
dc.contributor.authorMonsees, Thomas K.en_ZA
dc.contributor.authorBrooks, Nicole L.en_ZA
dc.contributor.authorOguntibeju, Oluwafemi Omoniyien_ZA
dc.date.accessioned2022-06-24T13:00:51Zen_ZA
dc.date.available2022-06-24T13:00:51Zen_ZA
dc.date.issued2020-11en_ZA
dc.descriptionCITATION: Alabi, T. D. et al. 2020. The Beneficial Role of Anchomanes difformis in STZ-Induced Reproductive Dysfunction in Male Wistar Rats. Diabetes, metabolic syndrome and obesity:targets and therapy, 13:4543–4560. doi:10.2147/DMSO.S270783en_ZA
dc.descriptionThe original publication is available at https://www.dovepress.com/diabetes-metabolic-syndrome-and-obesity-targets-and-therapy-journalen_ZA
dc.description.abstractBackground: Progression of diabetes mellitus has increasingly led to several diabetic complications. Diabetes is one of the major factors implicated in male reproductive system damage. Recent approaches such as the use of medicinal plants have been explored in the management of diabetes and associated complications. Anchomanes difformis (common name: children’s umbrella) has been shown to possess anti-diabetic ability in animal model. Therefore, this study seeks to investigate the potency of Achomanes difformis in ameliorating diabetes-induced reproductive dysfunction. Method: Type 2 diabetes was induced in male Wistar rats with 10% fructose administration for 2 weeks and an intraperitoneal injection of 40mg/kgBW of streptozotocin. Aqueous extract (200mg and 400mg/kgBW) of Anchomanes difformis leaves was administered daily for 6 weeks. The rats were randomly divided into 7 groups with a minimum of eight rats in each (8 rats in normal groups and 10 in diabetic groups). The impact of diabetes and treatment was investigated by estimating sperm concentration, motility indices, viability and morphological parameters in the normal, treatment controls and diabetic rats using CASA-SCA system. Histological examination of the testes and epididymis was performed. Results: Diabetes induction resulted in significant decrease in sperm concentration, viability and some motility parameters with 40% abnormalities in sperm morphology. The administration of Anchomanes difformis significantly increased sperm concentration and sperm viability, while it significantly improved the percentage of morphologically normal sperm in diabetic rats. Anchomanes difformis ameliorated testicular damage such as vacuolization and loss of germinal epithelium in the diabetic-treated rats when compared to the diabetic controls. Conclusion: The potency Anchomanes difformis displayed against diabetic-induced damage in the reproductive system might be a new and promising tool in the management of male reproductive dysfunctions and associated complications in diabetes mellitus.en_ZA
dc.description.urihttps://www.dovepress.com/the-beneficial-role-of-anchomanes-difformis-in-stz-induced-reproductiv-peer-reviewed-fulltext-article-DMSOen_ZA
dc.description.versionPublishers versionen_ZA
dc.format.extent18 pagesen_ZA
dc.identifier.citationAlabi, T. D. et al. 2020. The Beneficial Role of Anchomanes difformis in STZ-Induced Reproductive Dysfunction in Male Wistar Rats. Diabetes, metabolic syndrome and obesity:targets and therapy, 13:4543–4560. doi:10.2147/DMSO.S270783en_ZA
dc.identifier.issn1178-7007 (print)en_ZA
dc.identifier.otherdoi:10.2147/DMSO.S270783en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/125407en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherDove Pressen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectAnchomanes difformisen_ZA
dc.subjectDiabetes mellitusen_ZA
dc.subjectMale fertilityen_ZA
dc.subjectHerbs -- Therapeutic useen_ZA
dc.subjectMale reproductive systemen_ZA
dc.titleThe beneficial role of Anchomanes difformis in STZ-induced reproductive dysfunction in male Wistar ratsen_ZA
dc.typeArticleen_ZA
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