Integrated positron emission tomography/computed tomography for evaluation of mediastinal lymph node staging of non-small-cell lung cancer in a tuberculosis-endemic area : a 5-year prospective observational study

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dc.contributor.authorShaw, Jane A.en_ZA
dc.contributor.authorIrusen, Elvis M.en_ZA
dc.contributor.authorVon Groote-Bidlingmaier, Florianen_ZA
dc.contributor.authorWarwick, James M.en_ZA
dc.contributor.authorJeremic, Branislaven_ZA
dc.contributor.authorDu Toit, Rudolfen_ZA
dc.contributor.authorKoegelenberg, Coenraad F. N.en_ZA
dc.date.accessioned2016-07-28T10:17:08Z
dc.date.available2016-07-28T10:17:08Z
dc.date.issued2015
dc.descriptionCITATION: Shaw, J. A., et al. 2015. Integrated positron emission tomography/computed tomography for evaluation of mediastinal lymph node staging of non-small-cell lung cancer in a tuberculosis-endemic area : a 5-year prospective observational study. South African Medical Journal, 105(2):145-150, doi:10.7196/SAMJ.8357.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractBackground. Integrated positron emission tomography/computed tomography (PET-CT) is a well-validated modality for assessing mediastinal lymph node metastasis in non-small-cell lung cancer (NSCLC), which determines management and predicts survival. Tuberculosis (TB) is known to lead to false-positive PET-CT findings. Objectives. To assess the diagnostic accuracy of PET-CT in identifying mediastinal lymph node involvement of NSCLC in a high TB-endemic area. Methods. Patients who underwent both PET-CT and lymph node tissue sampling for the investigation of suspected NSCLC were prospectively included in this observational study. Results were analysed per patient and per lymph node stage. A post-hoc analysis was performed to test the validity of a maximum standardised uptake value (SUV­max) cut-off for lymph node positivity. Results. PET-CT had a sensitivity of 92.6%, specificity of 48.6%, positive predictive value of 56.8% and negative predictive value (NPV) of 90.0% in the per-patient analysis. Diagnostic accuracy was 67.2%. Similar values were obtained in the per-lymph node stage analysis. TB was responsible for 21.1% of false-positive results. A SUVmax cut-off of 4.5 yielded an improvement in diagnostic accuracy from 64.0% to 84.7% compared with a cut-off of 2.5, but at the cost of decreasing the NPV from 90.6% to 83.5%. Conclusion. In a high TB-endemic area, PET-CT remains a valuable method for excluding mediastinal lymph node involvement in NSCLC. Patients with a negative PET-CT may proceed to definitive management without further invasive procedures. However, PET-CT-positive lymph nodes require pathological confirmation, and the possibility of TB must be considered.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Geen opsomming beskikbaaraf_ZA
dc.description.urihttp://www.samj.org.za/index.php/samj/article/view/8357
dc.description.versionPublisher's version
dc.format.extent6 pagesen_ZA
dc.identifier.citationShaw, J. A., et al. 2015. Integrated positron emission tomography/computed tomography for evaluation of mediastinal lymph node staging of non-small-cell lung cancer in a tuberculosis-endemic area : a 5-year prospective observational study. South African Medical Journal, 105(2):145-150, doi:10.7196/SAMJ.8357
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.otherdoi:10.7196/SAMJ.8357
dc.identifier.urihttp://hdl.handle.net/10019.1/99266
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Group
dc.rights.holderHealth & Medical Publishing Group
dc.subjectNon-small-cell lung canceren_ZA
dc.subjectLymph nodes -- Canceren_ZA
dc.subjectTuberculosisen_ZA
dc.subjectLung canceren_ZA
dc.subjectComputerized emission tomographyen_ZA
dc.titleIntegrated positron emission tomography/computed tomography for evaluation of mediastinal lymph node staging of non-small-cell lung cancer in a tuberculosis-endemic area : a 5-year prospective observational studyen_ZA
dc.typeArticleen_ZA
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