Results from extended lymphadenectomies with [111In]PSMA-617 for intraoperative detection of PSMA-PET/CT-positive nodal metastatic prostate cancer

Simple item page
dc.contributor.authorJilg, Cordula A.en_ZA
dc.contributor.authorReichel, Kathrinen_ZA
dc.contributor.authorStoykow, Christianen_ZA
dc.contributor.authorRischke, H. C.en_ZA
dc.contributor.authorBartholoma, Marken_ZA
dc.contributor.authorDrendel, Vanessaen_ZA
dc.contributor.authorVon Buren, Moritzen_ZA
dc.contributor.authorSchultze-Seemann, Wolfgangen_ZA
dc.contributor.authorMeyer, Philipp T,en_ZA
dc.contributor.authorMix, Michaelen_ZA
dc.date.accessioned2020-03-09T06:23:08Z
dc.date.available2020-03-09T06:23:08Z
dc.date.issued2020-03-06
dc.descriptionCITATION: Jilg, C. A., et al. 2020. Results from extended lymphadenectomies with [111In]PSMA-617 for intraoperative detection of PSMA-PET/CT-positive nodal metastatic prostate cancer. EJNMMI Research, 10:17, doi:10.1186/s13550-020-0598-2.
dc.descriptionThe original publication is available at https://ejnmmires.springeropen.com
dc.description.abstractPurpose: Identification of suspicious PSMA-PET/CT-positive lymph node (LN) metastases (LNM) from prostate cancer (PCa) during lymphadenectomy (LA) is challenging. We evaluated an 111In-labelled PSMA ligand (DKFZ-617, referred to as [111In]PSMA-617) as a γ-emitting tracer for intraoperative γ-probe application for resected tissue samples in PCa patients. Forty-eight hours prior to LA, [111In]PSMA-617 was administered intravenously in 23 patients with suspected LNM on PSMA-PET/CT (n = 21 with biochemical relapse, n = 2 at primary therapy). Resected tissue samples (LN, LNM and fibrofatty tissue) were measured ex situ by a γ-probe expressed as counts per second (CPSnorm). [111In]PSMA-617 tissue sample uptake was measured by a germanium detector for verification and calculated as %IAlbm (percent injected activity per kilogram lean body mass at time of surgery). Based on a clinical requirement for a specificity > 95%, thresholds for both ex situ measurements were chosen accordingly. Correlation of the results from PET/CT, γ-probe and germanium detector with histopathology was done. Results: Eight hundred sixty-four LNs (197 LNM) were removed from 275 subregions in 23 patients, on average 8.6 ± 14.9 LNM per patient. One hundred four of 275 tissue samples showed cancer. Median γ-probe and germanium detector results were significantly different between tumour-affected (33.5 CPSnorm, 0.71 %IAlbm) and tumour-free subregions (3.0 CPSnorm, 0.03 %IAlbm) (each p value < 0.0001). For the chosen γ-probe cut-off (CPSnorm > 23) and germanium detector cut-off (%IAlbm > 0.27), 64 and 74 true-positive and 158 true-negative samples for both measurements were identified. Thirty-nine and 30 false-negative and 6 and 5 false-positive tissue samples were identified by γ-probe and germanium detector measurements. Conclusion: [111In]PSMA-617 application for LA is feasible in terms of an intraoperative real-time measurement with a γ-probe for detection of tumour-affected tissue samples. γ-probe results can be confirmed by precise germanium detector measurements and were significantly different between tumour-affected and tumour-free samples.en_ZA
dc.description.urihttps://ejnmmires.springeropen.com/articles/10.1186/s13550-020-0598-2
dc.description.versionPublisher's version
dc.format.extent13 pages : illustrationsen_ZA
dc.identifier.citationJilg, C. A., et al. 2020. Results from extended lymphadenectomies with [111In]PSMA-617 for intraoperative detection of PSMA-PET/CT-positive nodal metastatic prostate cancer. EJNMMI Research, 10:17, doi:10.1186/s13550-020-0598-2
dc.identifier.issn2191-219X (online)
dc.identifier.otherdoi:10.1186/s13550-020-0598-2
dc.identifier.urihttp://hdl.handle.net/10019.1/107594
dc.language.isoen_ZAen_ZA
dc.publisherSpringerOpen (part of Springer Nature)en_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectProstate canceren_ZA
dc.subjectLymphadenectomyen_ZA
dc.subjectGermanium detectorsen_ZA
dc.subjectDissectionen_ZA
dc.subjectMedical radiologyen_ZA
dc.titleResults from extended lymphadenectomies with [111In]PSMA-617 for intraoperative detection of PSMA-PET/CT-positive nodal metastatic prostate canceren_ZA
dc.typeArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
jilg_results_2020.pdf
Size:
2.65 MB
Format:
Adobe Portable Document Format
Description:
Download article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Radiation Oncology)