Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium

Simple item page
dc.cibjournalCITATION:Je-Yeon Yun, Premika S W Boedhoe, Chris Vriend, Neda Jahanshad, Yoshinari Abe, Stephanie H Ameis, Alan Anticevic, Paul D Arnold, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Yuqi Cheng, Kang Ik K Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Jamie D Feusner, Jean-Paul Fouche, Mònica Giménez, Patricia Gruner, Derrek P Hibar, Marcelo Q Hoexter, Hao Hu, Chaim Huyser, Keisuke Ikari, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Luisa Lazaro, Christine Lochner, Paulo Marques, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M Menchón, Luciano Minuzzi, Pedro Morgado, Pedro Moreira, Takashi Nakamae, Tomohiro Nakao, Janardhanan C Narayanaswamy, Erika L Nurmi, Joseph O’Neill, John Piacentini, Fabrizio Piras, Federica Piras, Y C Janardhan Reddy, Joao R Sato, H Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Michael C Stevens, Philip R Szeszko, David F Tolin, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Guido A van Wingen, Jian Xu, Xiufeng Xu, Qing Zhao, ENIGMA-OCD working group, Paul M Thompson, Dan J Stein, Odile A van den Heuvel, Jun Soo Kwon, Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium, Brain, Volume 143, Issue 2, February 2020, Pages 684–700, https://doi.org/10.1093/brain/awaa001
dc.contributor.authorYun, Je-Yeonen_ZA
dc.contributor.authorBoedhoe, Premika S Wen_ZA
dc.contributor.authorVriend, Chrisen_ZA
dc.contributor.authorJahanshad, Nedaen_ZA
dc.date.accessioned2022-04-19T19:14:36Z
dc.date.available2022-04-19T19:14:36Z
dc.date.issued2020-02
dc.description.abstractBrain structural covariance networks reflect covariation in morphology of different brain areas and are thought to reflect common trajectories in brain development and maturation. Large-scale investigation of structural covariance networks in obsessive-compulsive disorder (OCD) may provide clues to the pathophysiology of this neurodevelopmental disorder. Using T1-weighted MRI scans acquired from 1616 individuals with OCD and 1463 healthy controls across 37 datasets participating in the ENIGMA-OCD Working Group, we calculated intra-individual brain structural covariance networks (using the bilaterally-averaged values of 33 cortical surface areas, 33 cortical thickness values, and six subcortical volumes), in which edge weights were proportional to the similarity between two brain morphological features in terms of deviation from healthy controls (i.e. z-score transformed). Global networks were characterized using measures of network segregation (clustering and modularity), network integration (global efficiency), and their balance (small-worldness), and their community membership was assessed. Hub profiling of regional networks was undertaken using measures of betweenness, closeness, and eigenvector centrality. Individually calculated network measures were integrated across the 37 datasets using a meta-analytical approach. These network measures were summated across the network density range of K = 0.10-0.25 per participant, and were integrated across the 37 datasets using a meta-analytical approach. Compared with healthy controls, at a global level, the structural covariance networks of OCD showed lower clustering (P < 0.0001), lower modularity (P < 0.0001), and lower small-worldness (P = 0.017). Detection of community membership emphasized lower network segregation in OCD compared to healthy controls. At the regional level, there were lower (rank-transformed) centrality values in OCD for volume of caudate nucleus and thalamus, and surface area of paracentral cortex, indicative of altered distribution of brain hubs. Centrality of cingulate and orbito-frontal as well as other brain areas was associated with OCD illness duration, suggesting greater involvement of these brain areas with illness chronicity. In summary, the findings of this study, the largest brain structural covariance study of OCD to date, point to a less segregated organization of structural covariance networks in OCD, and reorganization of brain hubs. The segregation findings suggest a possible signature of altered brain morphometry in OCD, while the hub findings point to OCD-related alterations in trajectories of brain development and maturation, particularly in cingulate and orbitofrontal regions.en_ZA
dc.format.extent16 pages
dc.identifier.otherdoi.org/10.1093/brain/awaa061
dc.identifier.urihttp://hdl.handle.net/10019.1/124462
dc.language.isoen_ZAen_ZA
dc.rights.holderAuthors retain copyright
dc.subjectbrain structural covariance networken_ZA
dc.subjectgraph theoryen_ZA
dc.subjectobsessive-compulsive disorderen_ZA
dc.subjectpharmacotherapyen_ZA
dc.subjectillness durationen_ZA
dc.titleBrain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortiumen_ZA
dc.typeArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Yun_Boedhoe_Vriend_Jahanshad_et al_Brain structural covariance networks in_2020.pdf
Size:
1.45 MB
Format:
Adobe Portable Document Format
Description:
Main Article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Psychiatry)