Prevalence and determinants of congenital cytomegalovirus infection at a rural South African central hospital in the Eastern Cape

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dc.contributor.authorTshabalala, Donalden_ZA
dc.contributor.authorNewman, Howarden_ZA
dc.contributor.authorBusinge, Charlesen_ZA
dc.contributor.authorMabunda, Sikhumbuzo A.en_ZA
dc.contributor.authorKemp, Waldetteen_ZA
dc.contributor.authorBeja, Pakamaen_ZA
dc.date.accessioned2020-02-11T08:51:04Z
dc.date.available2020-02-11T08:51:04Z
dc.date.issued2018
dc.descriptionCITATION: Tshabalala, D., et al. 2018. Prevalence and determinants of congenital cytomegalovirus infection at a rural South African central hospital in the Eastern Cape. Southern African Journal of Infectious Diseases, 33(4):89-92, doi:10.1080/23120053.2018.1462560.
dc.descriptionThe original publication is available at https://sajid.co.za
dc.description.abstractBackground: The Nelson Mandela Academic Hospital (NMAH) in Mthatha, Eastern Cape, is a rural central hospital, serving one of the poorest districts in South Africa. The prevalence of and risk factors for congenital cytomegalovirus (CMV) in this area are not known. The aim was to evaluate the prevalence of congenital CMV and associated risk factors for babies born at NMAH. Methods: This was a cross-sectional study to determine the prevalence of congenital CMV infection among babies born at Nelson Mandela Academic Hospital. Mother–baby pairs delivered consecutively from Monday to Friday, who gave informed consent, were included. Demographic information was collected on a questionnaire. All babies were tested for congenital CMV using a saliva swab PCR within the first week of life. Results: A total of 302 births were assessed. Congenital CMV was prevalent in 18 births (5.96%; 95% CI 3.29–8.63) and had an equal prevalence between HIV-exposed and HIV-unexposed newborns (prevalence ratio [PR] = 1.00; 95% CI 0.94–1.06; p = 0.869). Conclusions: The prevalence of congenital CMV of 5.96% is similar to findings from other resource-limited settings. There was no significant association between maternal HIV status and congenital CMV. With the prevalence of congenital CMV being as high as it is in the studied setting, clinicians are advised to have a high index of suspicion, especially when mothers are CMV seropositive.en_ZA
dc.description.urihttps://sajid.co.za/index.php/sajid/article/view/155
dc.description.versionPublisher's version
dc.format.extent4 pages
dc.identifier.citationTshabalala, D., et al. 2018. Prevalence and determinants of congenital cytomegalovirus infection at a rural South African central hospital in the Eastern Cape. Southern African Journal of Infectious Diseases, 33(4):89-92, doi:10.1080/23120053.2018.1462560
dc.identifier.issn2313-1810 (online)
dc.identifier.issn2312-0053 (print)
dc.identifier.otherdoi:10.1080/23120053.2018.1462560
dc.identifier.urihttp://hdl.handle.net/10019.1/107465
dc.language.isoen_ZAen_ZA
dc.publisherMedpharm Publications
dc.rights.holderAuthors retain copyright
dc.subjectCongenital CMVen_ZA
dc.subjectCongenital disordersen_ZA
dc.subjectCytomegalovirus infections -- South Africa -- Eastern Cape -- Mthathaen_ZA
dc.subjectMother-to-child transmissionen_ZA
dc.titlePrevalence and determinants of congenital cytomegalovirus infection at a rural South African central hospital in the Eastern Capeen_ZA
dc.typeArticleen_ZA
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