The incidence and mortality of yellow fever in Africa : a systematic review and meta‑analysis

Simple item page
dc.contributor.authorNwaiwu, Akuoma U.en_ZA
dc.contributor.authorMusekiwa, Alfreden_ZA
dc.contributor.authorTamuzi, Jacques L.en_ZA
dc.contributor.authorSambala, Evanson Z.en_ZA
dc.contributor.authorNyasulu, Peter S.en_ZA
dc.date.accessioned2021-12-09T06:44:31Z
dc.date.available2021-12-09T06:44:31Z
dc.date.issued2019
dc.descriptionCITATION: Nwaiwu, A. U., et al. 2021. The incidence and mortality of yellow fever in Africa : a systematic review and meta‑analysis. BMC Infectious Diseases, 21:1089, doi:10.1186/s12879-021-06728-x.
dc.descriptionThe original publication is available at https://bmcinfectdis.biomedcentral.com
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund
dc.description.abstractBackground: Understanding the occurrence of yellow fever epidemics is critical for targeted interventions and control efforts to reduce the burden of disease. We assessed data on the yellow fever incidence and mortality rates in Africa. Methods: We searched the Cochrane Library, SCOPUS, MEDLINE, CINAHL, PubMed, Embase, Africa-wide and Web of science databases from 1 January 1975 to 30th October 2020. Two authors extracted data from included studies independently and conducted a meta-analysis. Results: Of 840 studies identified, 12 studies were deemed eligible for inclusion. The incidence of yellow fever per 100,000 population ranged from < 1 case in Nigeria, < 3 cases in Uganda, 13 cases in Democratic Republic of the Congo, 27 cases in Kenya, 40 cases in Ethiopia, 46 cases in Gambia, 1267 cases in Senegal, and 10,350 cases in Ghana. Case fatality rate associated with yellow fever outbreaks ranged from 10% in Ghana to 86% in Nigeria. The mortality rate ranged from 0.1/100,000 in Nigeria to 2200/100,000 in Ghana. Conclusion: The yellow fever incidence rate is quite constant; in contrast, the fatality rates vary widely across African countries over the study period. Standardized demographic health surveys and surveillance as well as accurate diagnostic measures are essential for early recognition, treatment and control.en_ZA
dc.description.urihttps://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-021-06728-x
dc.description.versionPublisher's version
dc.format.extent11 pages ; illustrations
dc.identifier.citationNwaiwu, A. U., et al. 2021. The incidence and mortality of yellow fever in Africa : a systematic review and meta‑analysis. BMC Infectious Diseases, 21:1089, doi:10.1186/s12879-021-06728-x
dc.identifier.issn1471-2334 (online)
dc.identifier.otherdoi:10.1186/s12879-021-06728-x
dc.identifier.urihttp://hdl.handle.net/10019.1/123543
dc.language.isoen_ZAen_ZA
dc.publisherBMC (part of Springer Nature)
dc.rights.holderAuthors retain copyright
dc.subjectYellow fever -- Incidence -- Africaen_ZA
dc.subjectYellow fever -- Patients -- Mortality -- Africaen_ZA
dc.subjectSystematic reviews (Medical research)en_ZA
dc.titleThe incidence and mortality of yellow fever in Africa : a systematic review and meta‑analysisen_ZA
dc.typeArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
nwaiwu_incidence_2021.pdf
Size:
1.45 MB
Format:
Adobe Portable Document Format
Description:
Download article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Epidemiology and Biostatistics)