Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses
Date
2013-12
Authors
Ayepola, Omolola R.
Chegou, Novel N.
Brooks, Nicole L.
Oguntibeju, Oluwafemi O.
Journal Title
Journal ISSN
Volume Title
Publisher
BioMed Central
Abstract
Background: Chronic inflammation plays a crucial role in hyperglycemia-induced liver injury. Kolaviron (KV), a natural biflavonoid from Garcinia kola seeds have been shown to possess anti- inflammatory properties which has not been explored in diabetes. To our knowledge, this is the first study to investigate the effect of KV on pro-inflammatory proteins in the liver of diabetic rats. Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg) in male Wistar rats. Kolaviron (100 mg/kg) was administered orally five times a week for six weeks. The concentrations of cytokines and chemokine were measured using Bio-plex Pro™ magnetic bead-based assays (Bio-Rad Laboratories, Hercules, USA). Plasma glucose and serum biomarkers of liver dysfunction were analyzed with diagnostic kits in an automated clinical chemistry analyzer. Insulin concentration was estimated by radioimmunoassay (RIA). Result: Kolaviron (100mg/kg) treatment significantly ameliorated hyperglycemia and liver dysfunction. Serum levels of hepatic marker enzymes were significantly reduced in kolaviron treated diabetic rats. Kolaviron prevented diabetes induced increase in the hepatic levels of proinflammatory cytokines; interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF-α) and monocyte chemotactic protein (MCP-1). Conclusion: The results of this study demonstrate that the hepatoprotective effects of kolaviron in diabetic rats may be partly associated with its modulating effect on inflammatory responses.
Description
Please cite as follows:
Ayepola, O. R., Chegou, N. N., Brooks, N. L. & Oguntibeju, O. O. 2013. Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses. BMC Complementary and Alternative Medicine, 13(1):363, doi:10.1186/1472-6882-13-363.
The original publication is available at http://www.biomedcentral.com/1472-6882/13/363
Ayepola, O. R., Chegou, N. N., Brooks, N. L. & Oguntibeju, O. O. 2013. Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses. BMC Complementary and Alternative Medicine, 13(1):363, doi:10.1186/1472-6882-13-363.
The original publication is available at http://www.biomedcentral.com/1472-6882/13/363
Keywords
Diabetes -- Complications, Chronic inflammation -- Complications, Liver diseases -- Prevention, Kolaviron, Animal experimentation, Hyperglycemia-induced liver injury -- Effect of chronic inflammation on
Citation
Ayepola, O. R., Chegou, N. N., Brooks, N. L. & Oguntibeju, O. O. 2013. Kolaviron, a Garcinia biflavonoid complex ameliorates hyperglycemia-mediated hepatic injury in rats via suppression of inflammatory responses. BMC Complementary and Alternative Medicine, 13(1):363, doi:10.1186/1472-6882-13-363.