Placental syphilis: a comprehensive review of routine histomorphology, HIV co-infection, penicillin treatment, immunohistochemistry, and polymerase chain reaction.

Simple item page
dc.contributor.advisorSchubert, Pawel Tomaszen_ZA
dc.contributor.authorMarais, Yolandi Anneen_ZA
dc.contributor.authorMason, Deidréen_ZA
dc.contributor.authorBarnard, Annelizeen_ZA
dc.contributor.authorSaaiman, Chestley Rashaellen_ZA
dc.contributor.authorEls, Hester Christineen_ZA
dc.contributor.authorKluge, Judithen_ZA
dc.contributor.authorGlass, Allison Joyen_ZA
dc.contributor.authorWright, Colleen Anneen_ZA
dc.contributor.authorSchubert, Pawel Tomaszen_ZA
dc.contributor.otherStellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Pathology. Division of Anatomical Pathology.en_ZA
dc.date.accessioned2023-11-22T10:28:46Zen_ZA
dc.date.accessioned2024-01-08T16:26:10Zen_ZA
dc.date.available2023-11-22T10:28:46Zen_ZA
dc.date.available2024-01-08T16:26:10Zen_ZA
dc.date.issued2023-04en_ZA
dc.descriptionThesis (MMed)--Stellenbosch University, 2023.en_ZA
dc.description.abstractENGLISH ABSTRACT: Introduction: Placental examination is useful to diagnose congenital syphilis. The classical histological diagnostic triad is, however, an infrequent finding. Additional morphological clues, special investigations, and knowledge of potential alterations by HIV co-infection and penicillin treatment can aid in making the diagnosis. Materials and methods: Placental specimens diagnosed with treponemal infection were reviewed. Morphological findings, IHC and qPCR results were assessed. Results: Two-hundred and twenty-two placentas were recruited. Villitis (93.2%), acute chorioamnionitis (91%) and villous immaturity (64%) were the most common abnormalities. HIV co-infection and penicillin treatment demonstrated alterations that may hamper diagnosis. Treponema IHC and q-PCR had a sensitivity of 74.4% and 25.81%, respectively and confirmed an additional 41 cases with negative or unknown serology. Conclusion: Villitis, acute chorioamnionitis and villous immaturity are the most common microscopic abnormalities in placental syphilis. HIV co-infection and penicillin treatment may alter morphology. Treponema IHC and q-PCR are useful adjuncts when serology is negative.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Geen opsomming beskikbaar.af_ZA
dc.description.versionMastersen_ZA
dc.format.extent42 pagesen_ZA
dc.identifier.urihttps://scholar.sun.ac.za/handle/10019.1/128936en_ZA
dc.language.isoen_ZAen_ZA
dc.language.isoen_ZAen_ZA
dc.publisherStellenbosch : Stellenbosch Universityen_ZA
dc.rights.holderStellenbosch University.en_ZA
dc.subject.lcshSyphilis, Congenital, hereditary, and infantileen_ZA
dc.subject.lcshTreponema pallidumen_ZA
dc.subject.lcshImmunohistochemistryen_ZA
dc.subject.lcshTreponema pallidumen_ZA
dc.subject.lcshSyphilis -- Diagnosisen_ZA
dc.titlePlacental syphilis: a comprehensive review of routine histomorphology, HIV co-infection, penicillin treatment, immunohistochemistry, and polymerase chain reaction.en_ZA
dc.typeThesisen_ZA
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
marais_placental_2023.pdf
Size:
2.63 MB
Format:
Adobe Portable Document Format
Description:
Download
Thumbnail Image
Name:
supplementary_material.pdf
Size:
968.67 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Masters Degrees (Anatomical Pathology)