Tuberculous Meningitis: Pathogenesis, Immune Responses, Diagnostic Challenges, and the Potential of Biomarker-Based Approaches

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dc.contributor.authorManyelo, Charles M.en_ZA
dc.contributor.authorSolomons, Regan S.en_Za
dc.contributor.authorWalzl, Gerharden_ZA
dc.contributor.authorChegou, Novel N.en_ZA
dc.date.accessioned2023-03-24T12:41:20Zen_ZA
dc.date.available2023-03-24T12:41:20Zen_ZA
dc.date.issued2021-02en_ZA
dc.descriptionCITATION: Manyelo CM, Solomons RS, Walzl G, Chegou NN. 2021. Tuberculous meningitis: pathogenesis, immune responses, diagnostic challenges, and the potential of biomarker-based approaches. J Clin Microbiol 59:e01771-20. doi.10.1128/JCM.01771-20.en_ZA
dc.descriptionThe original publication is available at: asm.orgen_ZA
dc.description.abstractTuberculous meningitis (TBM) is the most devastating form of tuberculosis (TB), causing high mortality or disability. Clinical management of the disease is challenging due to limitations of the existing diagnostic approaches. Our knowledge on the immunology and pathogenesis of the disease is currently limited. More research is urgently needed to enhance our understanding of the immunopathogenesis of the disease and guide us toward the identification of targets that may be useful for vaccines or host-directed therapeutics. In this review, we summarize the current knowledge about the immunology and pathogenesis of TBM and summarize the literature on existing and new, especially biomarker-based, approaches that may be useful in the management of TBM. We identify research gaps and provide directions for research which may lead to the development of new tools for the control of the disease in the near future.en_ZA
dc.description.versionPublisher’s versionen_ZA
dc.format.extent16 pagesen_ZA
dc.identifier.citationManyelo CM, Solomons RS, Walzl G, Chegou NN. 2021. Tuberculous meningitis: pathogenesis, immune responses, diagnostic challenges, and the potential of biomarker-based approaches. J Clin Microbiol 59:e01771-20. doi.10.1128/JCM.01771-20.en_ZA
dc.identifier.issn0095-1137 (print)en_ZA
dc.identifier.issn1098-660X (online)en_ZA
dc.identifier.otherdoi.10.1128/JCM.01771-20.en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/126712
dc.language.isoen_ZAen_ZA
dc.publisherAmerican Society for Microbiologyen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectMeninges -- Tuberculosisen_ZA
dc.subjectCentral nervous system -- Diseasesen_ZA
dc.subjectBiochemical markersen_ZA
dc.subjectImmune responseen_ZA
dc.subjectMeninges -- Pathogenesisen_ZA
dc.titleTuberculous Meningitis: Pathogenesis, Immune Responses, Diagnostic Challenges, and the Potential of Biomarker-Based Approachesen_ZA
dc.typeArticleen_ZA
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