An analysis of prognostic variables in acute lymphocytic leukaemia in a heterogenous South African population

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dc.contributor.authorWessels, G.
dc.contributor.authorHesseling, P. B.
dc.contributor.authorBuurman, M.
dc.contributor.authorOud, C.
dc.contributor.authorNel, E. D.
dc.date.accessioned2011-05-15T16:17:13Z
dc.date.available2011-05-15T16:17:13Z
dc.date.issued1997
dc.description.abstractThe records of all 96 children below the age of 15 years diagnosed with acute lymphoblastic leukaemia at Tygerberg Hospital in the Republic of South Africa between 1983 and 1995 were reviewed to determine risk factors which may predict poor outcome. Age < 2 and > 8 years, and white cell count > 20 x 109/l at diagnosis were significant predictors of poor outcome. Sex, FAB classification, immunophenotype, hepatomegaly, splenomegaly, BFM risk score, and the presence of mediastinal glands did not predict outcome. The presence of the established risk factors could not adequately explain the difference in 5-year event-free survival in the three ethnic groups which was 67 per cent in white, 17 per cent in black, and 38 per cent in children of mixed ethnic origin. In an attempt to improve survival in black children, our stratification of risk groups will in future be based on factors that include ethnicity, age and WCC ≤ 20 x 109/l at diagnosis. Pediatric oncology services in developing countries should adapt therapy to the risk factors of their local populations.
dc.description.versionArticle
dc.identifier.citationJournal of Tropical Pediatrics
dc.identifier.citation43
dc.identifier.citation3
dc.identifier.issn01426338
dc.identifier.urihttp://hdl.handle.net/10019.1/14121
dc.subjectacute lymphocytic leukemia
dc.subjectadolescent
dc.subjectage
dc.subjectarticle
dc.subjectcancer survival
dc.subjectchild
dc.subjectchildhood cancer
dc.subjectdeveloping country
dc.subjectethnic group
dc.subjectfemale
dc.subjecthepatomegaly
dc.subjecthuman
dc.subjectimmunophenotyping
dc.subjectleukocyte count
dc.subjectlymph node metastasis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmediastinum lymph node
dc.subjectprediction
dc.subjectprognosis
dc.subjectrisk factor
dc.subjectsex difference
dc.subjectsouth africa
dc.subjectsplenomegaly
dc.subjecttreatment outcome
dc.subjectAdolescent
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectEthnic Groups
dc.subjectFemale
dc.subjectHumans
dc.subjectIncidence
dc.subjectInfant
dc.subjectLeukemia, Lymphocytic, Acute
dc.subjectMale
dc.subjectPrognosis
dc.subjectProspective Studies
dc.subjectSouth Africa
dc.titleAn analysis of prognostic variables in acute lymphocytic leukaemia in a heterogenous South African population
dc.typeArticle
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