The chapter provides an overview of core issues in research on university-school partnerships in initial teacher education, including their purpose and intended benefits. The chapter shows how the notion of university-school partnerships can be understood in several ways, with varying permutations and models of partnership relationships. Concepts underpinning partnerships are outlined, as well as implications for teacher pedagogy and key considerations for universities and schools. The chapter highlights the need for partnerships to be founded on a sense of mutual benefit and collaboration by all involved.