Browsing by Author "Venter, W. D. Francois"

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    Low-dose stavudine trials: a public health priority for developing countries
    (AOSIS Publishing, 2012-03-13) Venter, W. D. Francois; Innes, Steve; Cotton, Mark
    The debate around relooking at stavudine dosing, both in terms of the adult low-dose stavudine study and more broadly, is welcome. The study being proposed to evaluate low-dose stavudine v. tenofovir is a fairly standard placebo-controlled non-inferiority study. The study design is not controversial; however, the choice of study drug has attracted critical attention.
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    Obesity is South Africa’s new HIV epidemic
    (South African Medical Association, 2024-03) Chandiwana, Nomathemba; Venter, W. D. Francois; Manne-Goehler, Jennifer M.; Wade, Alisha; Le Roux, Carel W.; Mbalati, Nzama Lawrence; Grimbeek, Angelika; Kruger, Petronell; Montsho, Eunice; Zimela, Zukiswa; Pillay Yogan; Dave, Joel A.; Murphy, Angela; Goldstein, Sue; Hofman, Karen; Mahomedy, Sameera; Thomas, Elizabeth; Mrara, Busi; Wing, Jeff; Lubbe, Jeanne; Koto, Zack; Conradie-Smit, Marli; Wharton, Sean; May, Wayne; Marr, Ian; Kaplan, Hilton; Forgan, Mariam; Alexander, Graham; Turner, John S.; Fourie, Gina; Hellig, Jocelyn Ann; Banks, Mandy; Ragsdale, Kim E.; Noeth, Marisa; Mohamed, Farzahna; Myer, Landon; Lebina, Limakatso; Maswime, Salome; Moosa, Yunus; Thomas, Teressa Sumy; Mbelle, Mzamo; Sinxadi, Phumla; Bekker, Linda-Gail; Bhana, Sindeep; Fabian, June; Decloedt, Eric; Bayat, Zaheer; Daya, Reyna; Bobat, Bilal; Storie, Fiona; Goedecke, Julia H.; Kahn, Kathleen; Tollman, Stephen; Mansfield, Brett; Siedner, Mark J.; Marconi, Vincent C.; Mody, Aaloke; Mtshali, Ntombifikile Nokwethemba; Geng, Elvin; Srinivasa, Suman; Ali, Mohammed K.; Lalla-Edwards, Samanta; Bentley, Alison; Wolvaardt, Gustaaf; Hill, Andrew; Nel, Jeremy
    Introduction: World Obesity Day is on 4 March 2024, and our nation needs to pay attention. As with the HIV epidemic in the 1990s, we are facing a calamitous threat to the health of the population that has been ignored for too long. Weight-related diseases have eclipsed tuberculosis (TB) and HIV as leading causes of morbidity and mortality. Over two-thirds of South African (SA) women are overweight or are living with obesity.[1] For example, type 2 diabetes, stroke and heart disease, conditions all directly linked to the disease of obesity, account for three of the top four causes of death nationally and incur massive health system costs.[2,3] Moreover, excess weight gain has deleterious effects far beyond cardiovascular disease risk, with evidence strongly linking it to poor pregnancy outcomes, cancer, liver and kidney disease, mental illness, and sleep disorders.[4,5].