Browsing by Author "Van Der Walt, J. J."

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    Cardiomyopathy in crowded rabbits : a preliminary report
    (Health & Medical Publishing Group, 1973) Weber, H. W.; Van Der Walt, J. J.
    Rabbits were crowded 4 to a cage for 2 wk, then released for 1 wk, crowded again for 1 wk, and so on. Of 44 rabbits subjected to intermittent crowding only 9 survived longer than 10 mth, 20 died during the 1st month and 15 died between the 2nd and 9th mth of the experiment. Autopsy findings were indicative of heart failure. Light microscopical sections of the myocardium showed myocytolysis, interstitial edema, and an increased amount of acid mucopolysaccharides in rabbits surviving for 2 wk and more. Some rabbits surviving longer than 2 wk had in addition coagulative myocardial necrosis. The accumulations of acid mucopolysaccharides apparently were unrelated to necrotic foci. Longtime survivors frequently showed myocardial fibrosis and endocardial fibro elastosis, as well as basophilic degeneration of myocardial fibers. The lesions observed were similar to those described in idiopathic endomyocardiopathy in Southern Africa. Therefore, the rabbit may be of some value for research in cardiomyopathies.
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    Electron microscopy of melanophagocytosis in the human skin window: technique and confirmation of the nature of the particle
    (Health & Medical Publishing Group, 1974) Wassermann, H. P.; Van Der Walt, J. J.; Lutz, U.; Tiedt, F. A. C.
    A modification of a tissue culture technique successfully applied to obtain preparations of the inflammatory response studied by the human skin window technique is described. Previously described melanin granules in macrophages in Cape colored responses could be shown to consist of nests of melanosomes.
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    Hereditary dysrhythmic congestive cardiomyopathy
    (Health & Medical Publishing Group, 1976) Brink, A. J.; Torrington, M.; Van Der Walt, J. J.
    A patient with hereditary congestive cardiomyopathy, who presented with recurrent episodes of life threatening ventricular arrhythmias most often precipitated by exercise, is described. The condition is marked by either a progressive course, in which case congestive cardiac failure may test in towards the end, or by unexpected sudden death. The family tree could be traced for 10 generations. The information about the tenth generation firmly established that 4 members, 2 of whom had died, were affected. Other evidence suggests that the condition was the cause of death in 3 members of the eighth generation.
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    Malacoplakia of the vagina : first case report
    (HMPG, 1973-08) Van Der Walt, J. J.; Marcus, P. B.; De Wet, J. J.; Burger, A. J. J.
    The first case of malacoplakia known to have affected the female genital tract is presented. This lesion involved the upper vagina and presented clinically as an infiltrating carcinoma. No evidence of malacoplakia of the urinary tract was found. A strong positive culture of E. coli, the light and electron microscopic findings, as well as the patient's rapid response to a broad-spectrum antibiotic, lend support to the current theory that malacoplakia may represent a peculiar response to infection with E. coli.
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    The significance of biochemical and structural changes in the development of the myocardiopathy of the Syrian hamster
    (1970) Lochner, A.; Brink, A. J.; Van Der Walt, J. J.
    In order to determine the causal factors in the development of the cardiomyopathy of the Syrian hamster, observations were made of myocardial histology, oxidative phosphorylation, high energy phosphate content, metabolism and mechanical activity of five age groups, ranging from 5 weeks to 10 months. Histological changes as well as biochemical abnormalities were present in the hearts of hamsters 5 weeks of age. With exception of a prolonged t-PH (time to peak height of contraction) period of the myopathic hearts of group I, tension development and contractility were normal up to 3 months of age. However, there was other evidence of disturbed function at 5 weeks of age, as shown by the length-tension curves. The significance and interrelationship of these findings are discussed. © 1970.