Browsing by Author "Schubert, Pawel T."

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    Endobronchial masses encountered on fine-needle aspiration biopsy : a focus on unusual entities
    (2020-04-24) Aldera, Alessandro P.; Schubert, Pawel T.
    Fine-needle aspiration biopsy (FNAB) is a useful technique in the evaluation of central lung tumors which is commonly encountered in clinical cytology practice. Some of these tumors may show endobronchial, polypoid growth which is readily apparent to the endoscopist. Pulmonary salivary gland-type tumors and carcinoid tumors are overall uncommon in the lung, but these tumors tend to occur centrally and show endobronchial involvement. The prognosis of these tumors is generally better than that of small cell or non-small cell carcinomas of the lung and more conservative surgical resection is often indicated. The identification of salient cytological features and a high index of suspicion when considering the differential diagnosis of a central lung tumor is essential to accurate diagnosis. This review focuses on cytological clues as well as ancillary techniques that may be useful to the practicing cytopathologist.
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    Pediatric Xanthogranulomatus cholangitis
    (Elsevier, 2018) Zbaidaa, Reda A.; Schubert, Pawel T.; Banieghbala, Behrouz
    ENGLISH ABSTRACT: The Xanthogranulomatous cholangitis is rare entity, usually it happens as an extension of Xanthogranuloma of the gall bladder (XCC) [1], although they are case reports of isolated Xanthogranulomatous cholangitis in adult age group [2] [3], To best of our knowledge this the first case of isolated Xanthogranulomatous cholangitis in pediatric age group.
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    Ultrathin bronchoscopy for solitary pulmonary lesions in a region endemic for tuberculosis : a randomised pilot trial
    (BioMed Central, 2016) Franzen, Daniel; Diacon, Andreas H.; Freitag, Lutz; Schubert, Pawel T.; Wright, Colleen A.; Schuurman, Mace M.
    Background: The evaluation of solitary pulmonary lesions (SPL) requires a balance between procedure-related morbidity and diagnostic yield, particularly in areas where tuberculosis (TB) is endemic. Data on ultrathin bronchoscopy (UB) for this purpose is limited. To evaluate feasibility and safety of UB compared to SB for diagnosis of SPL in a TB endemic region. Methods: In this prospective randomised trial we compared diagnostic yield and adverse events of UB with standard- size bronchoscopy (SB), both combined with fluoroscopy, in a cohort of patients with SPL located beyond the visible range of SB. Results: We included 40 patients (mean age 55.2 years, 45 % male) with malignant SPL ( n = 16; 40 %), tuberculous SPL ( n = 11; 27.5 %) and other benign SPL ( n = 13; 32.5 %). Mean procedure time in UB and SB was 30.6 and 26.0 min, respectively ( p = 0.15). By trend, adverse events were recorded more often with UB than with SB (30.0 vs. 5.0 %, p = 0.091), including extensive coughing ( n = 2), blocked working channel ( n = 2), and arterial hypertension requiring therapeutic intervention ( n = 1), all with UB. The overall diagnostic yield of UB compared to SB was 55.0 % vs. 80.0 %, respectively ( p = 0.18). Sensitivity for the diagnosis of malignancy of UB and SB was 50.0 % and 62.5 %, respectively ( p =0.95). Conclusion: UB is not superior to SB for the evaluation of SPL in a region endemic with tuberculosis, when combined with fluoroscopic guidance only. Trial registration: ClinicalTrials.gov (Identifier: NCT02490059).