Browsing by Author "Sandler, M."

Now showing 1 - 5 of 5
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    Acute febrile neutrophilic dermatosis (Sweet's syndrome). A report of 2 cases
    (Health & Medical Publishing Group, 1989-04) Jordaan, H. F.; De Goede, F. H.; Sandler, M.
    ENGLISH ABSTRACT: Two cases of Sweet's syndrome are described. The diagnostic criteria, clinical spectrum, complications, pertinent differential diagnoses and treatment modalities of this relatively rare clinical condition are described. The association of Sweet's syndrome with underlying haematological malignant disease is stressed.
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    Advanced osteitis fibrosa cystica in the absence of phalangeal subperiosteal resorption : a case report and review of the literature
    (Health & Medical Publishing Group, 1985) Wagener, G. W. W.; Sandler, M.; Hough, F. S.
    A case of primary hyperparathyroidism with advanced osteitis fibrosa cystica but without any subperiosteal phalangeal bone resorption is described. A review of this unusual rdiological feature is presented. High-detail magnification radiography (microradiography) is advocated for the early diagnosis of bony defects in hyperparathyroidism.
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    Cutaneous reaction to zinc - a rare complication of insulin treatment. A case report
    (Health & Medical Publishing Group, 1989) Sandler, M.; Jordaan, H. F.
    A diabetic patient presented with furunculoid lesions at the sites of insulin injections. These lesions were diagnosed as representing a manifestation of a cutaneous reaction to the zinc component of an intermediate-acting insulin. The differential diagnosis of furunculoid lesions in insulin-dependent diabetic subjects is discussed.
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    The genetics of diabetes mellitus, including the South African perspective
    (Health and Medical Publishing Group -- HMPG, 1984-09) Sandler, M.
    By and large, essential diabetes mellitus is thought to be 50% inherited and 50% environmental. In insulin dependent diabetes mellitus (IDDM) there is a strong link with the HLA-system with regard to the inheritance of susceptible diabetic genes, especially the DR3 and DR4 alleles. In IDDM environmental factors act in a predisposed individual to initiate an immune response with resultant beta-cell damage and destruction. Non-insulin-dependent diabetes mellitus (NIDDM) has no clear HLA link, but has been shown in studies of twins to have a stronger genetic basis than IDDM. In NIDDM environmental factors (race, ethnicity, diet, obesity) have an important influence on the clinical expression of the disease and the severity of complications in a genetically predisposed individual. The non-insulin-dependent diabetes of the young (NIDDY) variant and the phenomenon of chloropropamide-primed alcohol-induced flushing both underline the heterogeneity of NIDDM. Because of the heterogeneous nature and multifactorial inheritance pattern of diabetes mellitus, accurate genetic counseling is not possible as yet. However, data to date suggest that it is unwise to advise prospective parents not to procreate, since the overall risk of the development of clinical diabetes mellitus is extremely low.
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    Kallmann's syndrome with unilateral renal agenesis : a case report
    (Health & Medical Publishing Group, 1986) Honiball, S.; Sandler, M.
    A case of Kallmann's syndrome (hypogonadotrophic eunochoidism plus anosmia) in which further investigation revealed the association of unilateral renal agenesis is described. The importance of excretory urography in the investigation of patients with Kallmann's syndrome is stressed.