Browsing by Author "Madiba, T. E."

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    Preoperative anaemia and clinical outcomes in the South African surgical outcomes study
    (Health & Medical Publishing Group, 2018) Marsicano, D.; Hauser, N.; Roodt, F.; Cloete, E.; Conradie, W.; Morford, V.; Nel, D.; Bishop, D. G.; Madiba, T. E.; Biccard, B. M.
    Background. In high-income countries, preoperative anaemia has been associated with poor postoperative outcomes. To date, no large study has investigated this association in South Africa (SA). The demographics of SA surgical patients differ from those of surgical patients in the European and Northern American settings from which the preoperative anaemia data were derived. These associations between preoperative anaemia and postoperative outcomes are therefore not necessarily transferable to SA surgical patients. Objectives. The primary objective was to determine the association between preoperative anaemia and in-hospital mortality in SA adult non-cardiac, non-obstetric patients. The secondary objectives were to describe the association between preoperative anaemia and (i) critical care admission and (ii) length of hospital stay, and the prevalence of preoperative anaemia in adult SA surgical patients. Methods. We performed a secondary analysis of the South African Surgical Outcomes Study (SASOS), a large prospective observational study of patients undergoing inpatient non-cardiac, non-obstetric surgery at 50 hospitals across SA over a 1-week period. To determine whether preoperative anaemia is independently associated with mortality or admission to critical care following surgery, we conducted a multivariate logistic regression analysis that included all the independent predictors of mortality and admission to critical care identified in the original SASOS model. Results. The prevalence of preoperative anaemia was 1 727/3 610 (47.8%). Preoperative anaemia was independently associated with in-hospital mortality (odds ratio (OR) 1.657, 95% confidence interval (CI) 1.055 - 2.602; p=0.028) and admission to critical care (OR 1.487, 95% CI 1.081 - 2.046; p=0.015). Conclusions. Almost 50% of patients undergoing surgery at government-funded hospitals in SA had preoperative anaemia, which was independently associated with postoperative mortality and critical care admission. These numbers indicate a significant perioperative risk, with a clear need for quality improvement programmes that may improve surgical outcomes. Long waiting lists for elective surgery allow time for assessment and correction of anaemia preoperatively. With a high proportion of patients presenting for urgent or emergency surgery, perioperative clinicians in all specialties should educate themselves in the principles of patient blood management.
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    β and γ bands in N = 88 , 90, and 92 isotones investigated with a five-dimensional collective Hamiltonian based on covariant density functional theory : vibrations, shape coexistence, and superdeformation
    (American Physical Society, 2019-06-05) Majola, S. N. T.; Shi, Z.; Song, B. Y.; Li, Z. P.; Zhang, S. Q.; Bark, R. A.; Sharpey-Schafer, J. F.; Aschman, D. G.; Bvumbi, S. P.; Bucher, T. D.; Cullen, D. M.; Dinoko, T. S.; Easton, J. E.; Erasmus, N.; Greenlees, P. T.; Hartley, D. J.; Hirvonen, J.; Korichi, A.; Jakobsson, U.; Jones, P.; Jongile, S.; Julin, R.; Juutinen, S.; Ketelhut, S.; Kheswa, B. V.; Khumalo, N. A.; Lawrie, E. A.; Lawrie, J. J.; Lindsay, R.; Madiba, T. E.; Makhathini, L.; Maliage, S. M.; Maqabuka, B.; Malatji, K. L.; Masiteng, P. L.; Mashita, P. I.; Mdletshe, L.; Minkova, A.; Msebi, L.; Mullins, S. M.; Ndayishimye, J.; Negi, D.; Netshiya, A.; Newman, R.; Ntshangase, S. S.; Ntshodu, R.; Msebi, L.; Mullins, S. M.; Ndayishimye, J.; Negi, D.; Netshiya, A.; Newman, R.; Ntshangase, S. S.; Ntshodu, R.; Nyako, B. M.; Papka, P.; Peura, P.; Rahkila, P.; Riedinger, L. L.; Riley, M. A.; Roux, D. G.; Ruotsalainen, P.; Saren, J. J.; Scholey, C.; Shirinda, O.; Sithole, M. A.; Sorri, J.; Stankiewicz, M.; Stolze, S.; Timar, J.; Uusitalo, J.; Vymers, P. A.; Wiedeking, M.; Zimba, G. L.
    A comprehensive systematic study is made for the collective β and γ bands in even-even isotopes with neutron numbers N = 88 to 92 and proton numbers Z = 62 (Sm) to 70 (Yb). Data, including excitation energies, B(E0) and B(E2) values, and branching ratios from previously published experiments are collated with new data presented for the first time in this study. The experimental data are compared to calculations using a five-dimensional collective Hamiltonian (5DCH) based on the covariant density functional theory (CDFT). A realistic potential in the quadrupole shape parameters V (β,γ ) is determined from potential energy surfaces (PES) calculated using the CDFT. The parameters of the 5DCH are fixed and contained within the CDFT. Overall, a satisfactory agreement is found between the data and the calculations. In line with the energy staggering S(I) of the levels in the 2γ + bands, the potential energy surfaces of the CDFT calculations indicate γ -soft shapes in the N = 88 nuclides, which become γ rigid for N = 90 and N = 92. The nature of the 02 + bands changes with atomic number. In the isotopes of Sm to Dy, they can be understood as β vibrations, but in the Er and Yb isotopes the 02 + bands have wave functions with large components in a triaxial superdeformed minimum. In the vicinity of 152Sm, the present calculations predict a soft potential in the β direction but do not find two coexisting minima. This is reminiscent of 152Sm exhibiting an X(5) behavior. The model also predicts that the 03 + bands are of two-phonon nature, having an energy twice that of the 02 + band. This is in contradiction with the data and implies that other excitation modes must be invoked to explain their origin.