Browsing by Author "Macfarlane, C. M."
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- ItemAetiology of pulmonary dysfunction in total hip replacement operations: The influence of nifedipine on the factors involved(Health & Medical Publishing Group, 1987-05) Du Toit, H. J.; Macfarlane, C. M.; Taljaard, J. J. F.; King, J. B.; Cooper, R. C.ENGLISH ABSTRACT: Patients undergoing total hip replacement surgery who developed pulmonary dysfunction (PD) demonstrated evidence of a complement activation and increased thromboxane A2 (TXA2) synthesis. In a double-blind study nifedipine (Adalat; Bayer-Miles) was shown to inhibit complement activation and TXA2 synthesis and thus appears to offer protection against PD.
- ItemThe effect of ventilatory patterns on prostacyclin (PGI2) synthesis in the lung(Health & Medical Publishing Group, 1984) Du Toit, H. J.; Erasmus, F. R.; Macfarlane, C. M.; Taljaard, J. F.; Shephard, E. G.; King, J. B.; De Klerk, A. J.Prostacyclin (PGI2) appears to be synthesized in the lungs of man and experimental animals. It has been stated that PGI2 must be regarded as a local hormone that inhibits platelet adhesion to vessel walls only very close to the site of synthesis. The wide range of normal values given for PGI2 may be related to the sensitivity and exclusiveness of the different assay techniques used. In animals, hyperventilation increases PGI2 synthesis by the lung, but in agreement with other authors we demonstrated that hyperventilation did not influence PGI2 synthesis in man. We used a radio-immunoassay technique to estimate PGI2 levels.
- ItemObesity in perspective(Health & Medical Publishing Group, 1986) Macfarlane, C. M.Attitutes to obesity are changing. It is currently regarded as a common, multifactorial disorder with serious medical and psychological consequences. It is also resistant to treatment. Recent research with experimental animals has given new insights into the molecular pathology of this condition and gives some hope of novel therapeutic intervention.
- ItemValue of acetylated haemoglobin assay in fetal assessment(Health & Medical Publishing Group, 1987-5) Macfarlane, C. M.; Tsakalakos, N.; Taljaard, J. J. F.Acetylation of fetal haemoglobin, probably a posttranslational, intracellular, enzyme-mediated reaction, depends upon an adequate supply of glucose and oxygen to the fetus and the nature of the diabetes (if present) in the mother. These complicating factors limit the general usefulness of acetylated fetal haemoglobin assay in fetal assessment.