Browsing by Author "Jaskiewicz, K."

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    Endoscopic investigation for gastric cancer in a high-risk group
    (Health & Medical Publishing Group, 1992) Louwrens, H. D.; Jaskiewicz, K.; Van Wyk, M. J.; Kotze, T. J. V. W.; Brits, T. A.
    Early gastric cancer (EGC) was diagnosed in only a small percentage (<1%) of gastric cancer cases seen at Tygerberg Hospital over a 10-year period (1976-1985). This study, aimed at increasing the yield of EGC, was conducted in some high-incidence areas for gastric cancer. Coloured men, who are at high risk for gastric cancer, were identified by their medical practitioners and investigated. A total of 272 coloured males with nonspecific foregut symptoms underwent upper gastro-intestinal endoscopy and multiple biopsy specimens were obtained from all localised mucosal lesions. Twelve gastric cancers were histologically verified, of which 11 were diagnosed in males over 40 years of age. Two EGCs were diagnosed in older males, resulting in a markedly higher proportion of EGC in this subgroup (18,2%) than the proportion of EGC in inpatients at our institution (0,9%). Twenty-two per cent of males over 40 years of age had gastric ulcers compared with 9,2%. of younger males. Chronic atrophic gastritis was present in 56,2% of older males but in only 24,6% of younger males. Those over 40 years of age emerged as a subgroup with a high prevalence of gastric cancer and EGC, and concomitant conditions.
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    Helicobacter pylori prevalence in non-ulcer dyspepsia : ethnic and socio-economic differences
    (Health & Medical Publishing Group, 1993) Louw, J. A.; Jaskiewicz, K.; Girdwood, A. H.; Zak, J.; Trey, G.; Lucke, W.; Truter, H.; Kotze, V. W. T. J.
    Helicobacter pylori is an important cause of gastritis and a number of therapeutic trials suggest that it may be important in the genesis of duodenal ulcer recurrence. The reported prevalence of gastric colonisation by the organism varies considerably. The aim of this cross-sectional survey was to determine its prevalence in non-ulcer dyspeptics and to determine whether this is influenced by age, race, sex, socio-economic status, educational level and the number of persons sharing accommodation. One hundred and sixty-nine patients underwent endoscopy; biopsy specimens were taken from the antrum and H. pylori status was determined histologically. Gastric colonisation was found in 106 patients (63%). The prevalence showed a marked ethnic difference: 40% in whites and 71% in coloureds (P < 0,001). The ethnic groups were characterised by significant differences in socio-economic status (P < 10-6), educational level (P < 10-6), number of persons sharing accommodation (P < 10-6) and age (P < 0,001). These same differences were found when comparing the H. pylori-positive and negative groups, but were less marked and could be attributed to the marked differences between ethnic groups. We conclude that H. pylori prevalence differs between the ethnic groups studied. This may be because of varying degrees of exposure risk.